ALEXIDINE DIHYDROCHLORIDE

Synonym(s):1,1′-Hexamethylene-bis(5-[2-ethylhexyl]biguanide)

CAS NO.：22573-93-9
Empirical Formula: C26H56N10
Molecular Weight: 508.79
MDL number: MFCD00082369
EINECS: 245-096-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

What is ALEXIDINE DIHYDROCHLORIDE?

Chemical properties

White Powder with Light Yellow Cast

Originator

Alexidine ,Science Lab.

The Uses of ALEXIDINE DIHYDROCHLORIDE

Alexidine Dihydrochloride has antibacterial, antiplaque properties against Streptococcus mutans, Actinomyces ciscosus, and Actinomyces naesludii.

Definition

ChEBI: An amphipathic bisbiguanide with a structure consisting of two (2-ethylhexyl)guanide units linked by a hexamethylene bridge.

Manufacturing Process

A mixture of 16 g (0.09 mole) 1,1'-hexamethylene-bis(3-cyanoguanidine) and 20 d (0.12 mole) 2-ethylhexylamine hydrochloride is heated at 150-155°C for 3 hours. The mixture is cooled and the product is dissolved in 75 ml of hot water. The solution is treated with activated charcoal. 1,1'-Hexamethylene-bis- (5-(ethylhexyl)biguanide) is recrystalluized from methanol-ether, melting point 220.6-223.4°C.

Therapeutic Function

Antiseptic

Properties of ALEXIDINE DIHYDROCHLORIDE

Melting point:	220-224
Boiling point:	574.5±60.0 °C(Predicted)
Density	1.10±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Methanol (Slightly)
form	Solid
pka	12.34±0.10(Predicted)
color	White to Off-White