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HomeProduct name listAdenosine 5'-monophosphate monohydrate

Adenosine 5'-monophosphate monohydrate

Synonym(s):5′-AMP;A-5′-P;AMP

  • CAS NO.:18422-05-4
  • Empirical Formula: C10H16N5O8P
  • Molecular Weight: 365.24
  • MDL number: MFCD00149360
  • EINECS: 200-500-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Adenosine 5'-monophosphate monohydrate Structural

What is Adenosine 5'-monophosphate monohydrate?

Chemical properties

White crystalline powder

The Uses of Adenosine 5'-monophosphate monohydrate

Nutrient;Ca++ channel block

The Uses of Adenosine 5'-monophosphate monohydrate

Adenosine 5′-monophosphate (5′AMP) is suitable for use as

  • a reagent in the synthesis of adenosine-5′-phosphoimidazolide
  • an activator of phosphorylase b in the polymerization reaction for the synthesis of branched polysaccharides
  • an inhibitor of endogenous NMN adenylyltransferase (NMNAT) activity that converts NMN to NAD+

Definition

ChEBI: Adenosine 5'-monophosphate monohydrate is a purine ribonucleoside monophosphate.

Biochem/physiol Actions

Adenosine 5′-monophosphate (5′-AMP) has many uses in nature. 5′-AMP is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). AMP inhibits dephosphorylation of AMPK and promotes phosphorylation of AMPK by upstream kinases.

Purification Methods

The acid has been recrystallised from H2O (fine needles) and is freely soluble in boiling H2O. It crystallises also from H2O on addition of acetone. Alternatively purify it by chromatography on Dowex 1 (in formate form), eluting with 0.25M formic acid. It is then adsorbed onto charcoal (which had been boiled for 15minutes with M HCl, washed free of chloride and dried at 100o) and recovered by stirring three times with isoamyl alcohol/H2O (1:9 v/v). The aqueous layer from the combined extracts is evaporated to dryness under reduced pressure, and the product is crystallised twice from hot H2O. [Morrison & Doherty Biochem J 79 433 1961]. It has max 259nm ( 15,400) in H2O at pH 7.0. [Alberty et al. J Biol Chem 193 425 1951, Martell & Schwarzenbach Helv Chim Acta 39 653 1956]. The acridinium salt has m 208o [Baddiley & Todd J Chem Soc 648 1947, Pettit Synthetic Nucleotides, van Nostrand-Reinhold, NY, Vol 1 252 1972, NMR: Sarma et al. J Am Chem Soc 96 7337 1974, Norton et al. J Am Chem Soc 98 1007 1976, IR of diNa salt: Miles Biochem Biophys Acta 27 324 1958]. [Beilstein 26 III/IV 3615.]

Properties of Adenosine 5'-monophosphate monohydrate

Melting point: 183-188 °C (dec.)(lit.)
alpha  -48 º (c=2% in 2% NaOH)
FEMA  4224 | ADENOSINE MONOPHOSPHATE; MONOSODIUM, OR DISODIUM ADENYLATE
storage temp.  -20°C
solubility  H2O: with addition of mild alkalisoluble
form  Solid
color  White to Off-White
Merck  14,158
BRN  5205540
CAS DataBase Reference 18422-05-4(CAS DataBase Reference)

Safety information for Adenosine 5'-monophosphate monohydrate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Adenosine 5'-monophosphate monohydrate

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