Adenosine 5'-monophosphate monohydrate
Synonym(s):5′-AMP;A-5′-P;AMP
- CAS NO.:18422-05-4
- Empirical Formula: C10H16N5O8P
- Molecular Weight: 365.24
- MDL number: MFCD00149360
- EINECS: 200-500-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 21:13:59
What is Adenosine 5'-monophosphate monohydrate?
Chemical properties
White crystalline powder
The Uses of Adenosine 5'-monophosphate monohydrate
Nutrient;Ca++ channel block
The Uses of Adenosine 5'-monophosphate monohydrate
Adenosine 5′-monophosphate (5′AMP) is suitable for use as
- a reagent in the synthesis of adenosine-5′-phosphoimidazolide
- an activator of phosphorylase b in the polymerization reaction for the synthesis of branched polysaccharides
- an inhibitor of endogenous NMN adenylyltransferase (NMNAT) activity that converts NMN to NAD+
Definition
ChEBI: Adenosine 5'-monophosphate monohydrate is a purine ribonucleoside monophosphate.
Biochem/physiol Actions
Adenosine 5′-monophosphate (5′-AMP) has many uses in nature. 5′-AMP is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). AMP inhibits dephosphorylation of AMPK and promotes phosphorylation of AMPK by upstream kinases.
Purification Methods
The acid has been recrystallised from H2O (fine needles) and is freely soluble in boiling H2O. It crystallises also from H2O on addition of acetone. Alternatively purify it by chromatography on Dowex 1 (in formate form), eluting with 0.25M formic acid. It is then adsorbed onto charcoal (which had been boiled for 15minutes with M HCl, washed free of chloride and dried at 100o) and recovered by stirring three times with isoamyl alcohol/H2O (1:9 v/v). The aqueous layer from the combined extracts is evaporated to dryness under reduced pressure, and the product is crystallised twice from hot H2O. [Morrison & Doherty Biochem J 79 433 1961]. It has max 259nm ( 15,400) in H2O at pH 7.0. [Alberty et al. J Biol Chem 193 425 1951, Martell & Schwarzenbach Helv Chim Acta 39 653 1956]. The acridinium salt has m 208o [Baddiley & Todd J Chem Soc 648 1947, Pettit Synthetic Nucleotides, van Nostrand-Reinhold, NY, Vol 1 252 1972, NMR: Sarma et al. J Am Chem Soc 96 7337 1974, Norton et al. J Am Chem Soc 98 1007 1976, IR of diNa salt: Miles Biochem Biophys Acta 27 324 1958]. [Beilstein 26 III/IV 3615.]
Properties of Adenosine 5'-monophosphate monohydrate
Melting point: | 183-188 °C (dec.)(lit.) |
alpha | -48 º (c=2% in 2% NaOH) |
FEMA | 4224 | ADENOSINE MONOPHOSPHATE; MONOSODIUM, OR DISODIUM ADENYLATE |
storage temp. | -20°C |
solubility | H2O: with addition of mild alkalisoluble |
form | Solid |
color | White to Off-White |
Merck | 14,158 |
BRN | 5205540 |
CAS DataBase Reference | 18422-05-4(CAS DataBase Reference) |
Safety information for Adenosine 5'-monophosphate monohydrate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Adenosine 5'-monophosphate monohydrate
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