9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2

CAS NO.：61263-35-2
Empirical Formula: C23H38O4
Molecular Weight: 378.55
MDL number: MFCD01723635
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is 9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2?

The Uses of 9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2

9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 (PGE2; ) with an extended half-life in vivo. In combination with various other prostaglandin derivatives, it results in the termination of first trimester pregnancy in monkeys. A single intramuscular injection containing 0.5 mg of meteneprost and 7.5 mg of 17-phenyl trinor PGF1α is very effective in terminating early pregnancy. This prostaglandin mixture is ineffective on monkeys in their third trimester of pregnancy. Meteneprost, when compared to PGE2 and PGF1α, in monkey and rat, does not result in unwanted side effects such as fever or gastrointestinal problems.

The Uses of 9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2

Meteneprost is a potent analog of Prostaglandin E2 (PGE2) (P838610). Meteneprost in combination with various other prostaglandin derivatives is used for medical termination of early pregnancy.

What are the applications of Application

9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 is meteneprost, a potent metabolism resistant analog of PGE2

Definition

ChEBI: 9-Deoxy-9-methylene-16,16-dimethyl -PGE2 is a long-chain fatty acid.

Properties of 9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2

Boiling point:	426.61°C (rough estimate)
Density	1.0037 (rough estimate)
refractive index	1.4433 (estimate)
storage temp.	Store at -20°C
solubility	DMF: >100 mg/ml (from PGE2); DMSO: >100 mg/ml (from PGE2); Ethanol: >100 mg/ml (from PGE2); PBS pH 7.2: >5 mg/ml (from PGE2)
pka	4.76±0.10(Predicted)