8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
Synonym(s):8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride
- CAS NO.:75704-24-4
- Empirical Formula: C11H11Cl2N3O
- Molecular Weight: 272.13
- MDL number: MFCD06411596
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:03
What is 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE?
The Uses of 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one is a selective 5-hydroxytryptamine 2C receptor agonist with putative antidepressant like properties. It also blocks and decreases baseline nicotine-induced locomotor activity in rats.
Biological Activity
Potent and selective 5-HT 2C receptor agonist (K i = 4 nM; EC 50 = 12 nM). Antidepressant following systemic administration in vivo .
Properties of 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
Boiling point: | 513.9±50.0 °C(Predicted) |
Density | 1.54±0.1 g/cm3(Predicted) |
storage temp. | Desiccate at RT |
solubility | DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml |
form | A crystalline solid |
pka | 12.09±0.20(Predicted) |
color | Off-white to light yellow |
Safety information for 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
Computed Descriptors for 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin E (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin G 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 4-Bromo-N,N-bis(4-iodophenyl)aniline 2-Chloro-3-(chloromethyl)pyridine 3,3,6,6-Tetramethylcyclohexane-1,2-dione 1-(4-Fluorophenyl)piperidin-2-one Benzene butanoic acid, 2-hydroxy-3-iodo-, methyl ester 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (4R,12aR)-7-Methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1`,2`;4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid 4-bromopyrimidin-2-amine 3-bromo-5-fluorobenzaldehyde 6-bromopyridazin-3-amineRelated products of tetrahydrofuran
Methylamine hydrochloride
Trimethylamine hydrochloride
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1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE
WAP (E-8)
N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE
WATER, ELECTROPHORESIS GRADE
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