8-O-acetyl shanzhiside methyl ester
Synonym(s):Barlerin;Umbroside
- CAS NO.:57420-46-9
- Empirical Formula: C19H28O12
- Molecular Weight: 448.42
- MDL number: MFCD15071141
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 8-O-acetyl shanzhiside methyl ester?
Chemical properties
Off-white crystalline powder, easily soluble in methanol and ethanol, derived from unique flavor.
The Uses of 8-O-acetyl shanzhiside methyl ester
8-O-acetyl shanzhiside methyl ester can be used for content determination, identification and pharmacological experiments, etc. It can activate congestion, relieve pain and stop bleeding.
in vitro
Treatment of SH-SY5Y cells with 8-O-Acetyl shanzhiside methyl ester blocks TNF-α-induced nuclear transcription factor κB (NF-κB) activation and decreases high-mobility group box-1 ( HMGB-1) expression . Treatment of H9c2 cells with it 9 μM blocks TNF-α-induced NF-κB phosphorylation by blocking High-mobility group box1 (HMGB1) expression.
in vivo
8-O-Acetyl shanzhiside methyl ester significantly promotes angiogenesis in the ischaemic brain and improves functional outcome after stroke. It also significantly increases vascularization compared with vehicle treatment. 8-O-Acetyl shanzhiside methyl ester significantly shortens capillary blood clotting time and reduces blood loss volume, but does not influence mice activated partial thromboplastin time , prothrombin time or thrombin time.
Properties of 8-O-acetyl shanzhiside methyl ester
Boiling point: | 634.2±55.0 °C(Predicted) |
Density | 1.52 |
solubility | Soluble in methan |
form | powder |
pka | 12.80±0.70(Predicted) |
color | White |
Safety information for 8-O-acetyl shanzhiside methyl ester
Computed Descriptors for 8-O-acetyl shanzhiside methyl ester
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