Dimethyl acetylsuccinate

Synonym(s):2-Acetylbutanedioic acid-1,4-dimethyl ester

CAS NO.：10420-33-4
Empirical Formula: C8H12O5
Molecular Weight: 188.18
MDL number: MFCD00008448
EINECS: 233-897-4
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:34

What is Dimethyl acetylsuccinate?

The Uses of Dimethyl acetylsuccinate

Dimethyl Acetylsuccinate was used in preparation of β-carbolines via diastereo- and enantioselective Bronsted acid catalyzed N-acyliminium cyclization cascades of tryptamines and keto acids/esters.

The Uses of Dimethyl acetylsuccinate

Dimethyl acetylsuccinate has been used in the synthesis of 2-oxofuro[2,3-b]pyrroles and 19-methyl-15-oxa-20-azatricyclo[12.3.3.0(1,14)]icos-18-en-18-carboxylates.

General Description

Dimethyl acetylsuccinate undergoes sulfuric acid catalyzed Pechmann condensation with the corresponding resorcinol derivative to give 7-hydroxycoumarins.

Properties of Dimethyl acetylsuccinate

Melting point:	33 °C (lit.)
Boiling point:	129-134 °C/12 mmHg (lit.)
Density	1.16 g/mL at 25 °C (lit.)
vapor pressure	19.6Pa at 25℃
Flash point:	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	30g/l OECD Test Guideline 105
form	Notspecified
pka	10.53±0.59(Predicted)
color	White or Colorless to Almost white or Almost colorless
explosive limit	0.72-11.1%(V)
CAS DataBase Reference	10420-33-4(CAS DataBase Reference)
EPA Substance Registry System	Butanedioic acid, acetyl-, dimethyl ester (10420-33-4)

Safety information for Dimethyl acetylsuccinate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.