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HomeProduct name list8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

Synonym(s):8-Br-cAMP;8-Bromo-cAMP, Na;Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3 - Calbiochem

8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT Structural

What is 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT?

Chemical properties

Off-white powder

The Uses of 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt has been used:

  • to study its effect on fas and caspase-3 mRNA expression and on P4 production in bovine mid luteal cell culture
  • used to treat choriocarcinoma BeWo cell line and study its effect on cell viability, apoptosis and morphological changes in the nuclei
  • in superfusion medium for head kidneys stimulation

What are the applications of Application

8-Bromo-cAMP is a cell-permeable cyclic AMP (cAMP) analog that preferentially activates cAMP-dependent PKA.

General Description

8-Bromoadenosine 3′:5′-cyclic monophosphate is a brominated cyclic mononucleotide.

Biological Activity

Cell-permeable cAMP analog; activator of protein kinase A. Also available as part of the PKA Tocriset™ .

Biochem/physiol Actions

Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.

storage

-20°C (desiccate)

Properties of 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

Melting point: >264°C )dec._
storage temp.  -20°C
solubility  H2O: 100 mg/mL
form  powder
color  off-white
Water Solubility  Soluble in water (100mM)
BRN  7739743
Stability: Hygroscopic, Moisture Sensitive

Safety information for 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

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