8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

Synonym(s):8-Br-cAMP;8-Bromo-cAMP, Na;Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3 - Calbiochem

CAS NO.：76939-46-3
Empirical Formula: C10H12BrN5NaO6P
Molecular Weight: 432.1
MDL number: MFCD00005844
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 15:53:33

8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT Structural

What is 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT?

Chemical properties

Off-white powder

The Uses of 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt has been used:

to study its effect on fas and caspase-3 mRNA expression and on P4 production in bovine mid luteal cell culture
used to treat choriocarcinoma BeWo cell line and study its effect on cell viability, apoptosis and morphological changes in the nuclei
in superfusion medium for head kidneys stimulation

What are the applications of Application

8-Bromo-cAMP is a cell-permeable cyclic AMP (cAMP) analog that preferentially activates cAMP-dependent PKA.

General Description

8-Bromoadenosine 3′:5′-cyclic monophosphate is a brominated cyclic mononucleotide.

Biological Activity

Cell-permeable cAMP analog; activator of protein kinase A. Also available as part of the PKA Tocriset™ .

Biochem/physiol Actions

Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.

storage

-20°C (desiccate)

Properties of 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

Melting point:	>264°C )dec._
storage temp.	-20°C
solubility	H₂O: 100 mg/mL
form	powder
color	off-white
Water Solubility	Soluble in water (100mM)
BRN	7739743
Stability:	Hygroscopic, Moisture Sensitive

Safety information for 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.