7-Methylquinoline

CAS NO.：612-60-2
Empirical Formula: C10H9N
Molecular Weight: 143.19
MDL number: MFCD00006805
EINECS: 210-316-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:07:02

What is 7-Methylquinoline?

Chemical properties

white to light yellow crystal powder

The Uses of 7-Methylquinoline

7-methylquinoline has been bioassayed as tumor initiator on the skin of Sencar mice.

General Description

7-Methylquinoline is a reagent used in the preparation of diarylmethylpiperazines as potent opioid receptor agonists with improved side effects. Also used in the preparation of novel pyrazine compounds derived from 2-phenylquinolin-7-yl which act as potent insulin-like growth factor-I receptor inhibitors.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

7-Methylquinoline may be sensitive to exposure to light. May react vigorously with strong oxidizing agents and strong acids . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Fire Hazard

7-Methylquinoline is combustible.

Purification Methods

Purify it via its dichromate complex (m 149o, after five recrystallisations from water). [Cumper et al. J Chem Soc 1176 1962, Beilstein 20 III/IV 3497, 20/7 V 402.]

Properties of 7-Methylquinoline

Melting point:	35-37 °C(lit.)
Boiling point:	258 °C(lit.)
Density	1.061
refractive index	1.6070 to 1.6210
Flash point:	>230 °F
storage temp.	Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Viscous Liquid
pka	5.44±0.14(Predicted)
color	Off-White to Pale Beige Low-Melting
Water Solubility	<0.1 g/100 mL at 20 ºC
BRN	110317
Stability:	Stable. Incompatible with strong oxidizing agents, strong acids. May be light sensitive.
CAS DataBase Reference	612-60-2(CAS DataBase Reference)
NIST Chemistry Reference	Quinoline, 7-methyl-(612-60-2)
EPA Substance Registry System	7-Methylquinoline (612-60-2)

Safety information for 7-Methylquinoline

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H341:Germ cell mutagenicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.