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HomeProduct name listN-EPSILON-ACETYL-L-LYSINE

N-EPSILON-ACETYL-L-LYSINE

  • CAS NO.:692-04-6
  • Empirical Formula: C8H16N2O3
  • Molecular Weight: 188.22
  • MDL number: MFCD00002639
  • EINECS: 211-725-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 08:26:49
N-EPSILON-ACETYL-L-LYSINE Structural

What is N-EPSILON-ACETYL-L-LYSINE?

Description

Acetyllysine (or acetylated lysine) is an acetyl-derivative of the amino acid lysine. There are multiple forms of acetyllysine - this article refers to N-ε-acetyl-L-lysine. The other form is N-α-acetyl-Llysine.
In proteins, the acetylation of lysine residues is an important mechanism of epigenetics. It functions by regulating the binding of histones to DNA in nucleosomes and thereby controlling the expression of genes on that DNA. Non-histone proteins are acetylated as well. Unlike the functionally similar methyllysine, acetyllysine does not carry a positive charge on its side chain.
Histone acetyltransferases (HATs) catalyze the addition of acetyl groups from acetyl-CoA onto certain lysine residues of histones and non-histone proteins. Histone deacetylases (HDACs) catalyze the removal of acetyl groups from acetylated lysines.
Acetyllysine can be synthesized from lysine by the selective acetylation of the terminal amine group.

Chemical properties

white crystalline powder

The Uses of N-EPSILON-ACETYL-L-LYSINE

N-Epsilon-acetyl-l-lysine is used in the metabolomics study on the combined effect of cocaine and ethanol via liquid chromatography-mass spectrometry metabolomics approach.

What are the applications of Application

Nepsilon-Acetyl-L-lysine is an amino acid derivative with an acetyl group at the ε nitrogen

Definition

ChEBI: An N6-acyl-L-lysine where the N6-acyl group is specified as acetyl.

Biochem/physiol Actions

Nε-Acetyl-L-lysine (L-AcK) is an R-chain N-acetylated α amino acid used together with other lysine analogues to differentiate and characterized various aminoacylases and regulator 2 (Sir2) enzymes/sirtuins.

Properties of N-EPSILON-ACETYL-L-LYSINE

Melting point: 250 °C (dec.)(lit.)
Boiling point: 323.23°C (rough estimate)
Density  1.1793 (rough estimate)
refractive index  1.4500 (estimate)
storage temp.  -20°C
solubility  Aqueous Base (Slightly), Water (Slightly)
pka 2.53±0.24(Predicted)
form  Powder
color  White
Water Solubility  Soluble in water (miscible), and 80% acetic acid (50 mg/ml).
Sensitive  Hygroscopic
CAS DataBase Reference 692-04-6(CAS DataBase Reference)

Safety information for N-EPSILON-ACETYL-L-LYSINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for N-EPSILON-ACETYL-L-LYSINE

InChIKey DTERQYGMUDWYAZ-ZETCQYMHSA-N

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