6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE
Synonym(s):4-Amino-5-bromo-2-hydroxypyrimidine
- CAS NO.：2240-25-7
- Empirical Formula: C4H4BrN3O
- Molecular Weight: 190
- MDL number: MFCD00056025
- EINECS: 218-806-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE?
Chemical properties
LIGHT YELLOW AMORPHOUS POWDER
The Uses of 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE
4-Amino-5-bromo-2-hydroxypyrimidine can be used in the synthesis of cross-link products under anaerobic and aerobic conditions.
The Uses of 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE
5-Bromocytosine was used in the synthesis of five cross-link products- C[5-N6]A, C[5-2]A, C[5-8]A, A[2-5]C, and A[8-5]C, under both aerobic and anaerobic conditions.
What are the applications of Application
5-Bromocytosine is a potent anti-HIV agent
General Description
5-Bromocytosine derivative (β isomer) is a potent anti-HIV agent.
Purification Methods
5-Bromocytosine is recrystallised from H2O or 50% aqueous EtOH. Alternatively, dissolve ca 3g in conc HCl (10mL) and evaporate to dryness. Dissolve the residual hydrochloride in the minimum volume of warm H2O and make faintly alkaline with aqueous NH3. Collect the crystals and dry them in a vacuum at 100o. [Hilbdert & Jensen J Am Chem Soc 56 134 1934, Beilstein 25 III/IV 3689.]
Properties of 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE
| Melting point: | 240-243 °C (dec.) (lit.) |
| Density | 1.7513 (rough estimate) |
| refractive index | 1.6520 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in formic acid (50 mg/ml). |
| form | Solid |
| pka | 7.34±0.10(Predicted) |
| color | White to yellow |
| BRN | 127286 |
| NIST Chemistry Reference | 5-Bromocytosine(2240-25-7) |
Safety information for 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE
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