5-Chlorouracil
Synonym(s):5-Chloro-2,4-dihydroxypyrimidine;5-Chloropyrimidine-2,4(1H,3H)-dione;5-Chlorouracil;Fluorouracil Impurity E (PhEur)
- CAS NO.：1820-81-1
- Empirical Formula: C4H3ClN2O2
- Molecular Weight: 146.53
- MDL number: MFCD00006019
- EINECS: 217-339-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-22 13:52:55
What is 5-Chlorouracil?
Chemical properties
white to light beige crystalline powder
The Uses of 5-Chlorouracil
5-Chlorouracil can be used for the experimental and clinical treatment of neoplastic and viral diseases.
The Uses of 5-Chlorouracil
5-Chlorouracil was used as a control in resazurin-based cytotoxicity assay for screening of cytotoxicity in hepatocytes and liver cell lines.
What are the applications of Application
5-Chlorouracil is used for the development of experimental therapies for viral and neoplastic diseases
Definition
ChEBI: An organochlorine compound consisting of uracil having an chloro substituent at the 5-position.
General Description
The shape resonance spectra of 5-chlorouracil, obtained from fixed-nuclei elastic scattering calculations by the Schwinger multichannel method with pseudopotentials, was studied.
Purification Methods
It recrystallises from hot H2O (4g/500mL) using charcoal. [McOmie et al. J Chem Soc 3478 1955, West & Barrett J Am Chem Soc 76 3146 1954, Beilstein 24 III/IV 1231.]
Properties of 5-Chlorouracil
| Melting point: | >300 °C (lit.) |
| Density | 1.6838 (rough estimate) |
| refractive index | 1.6550 (estimate) |
| storage temp. | 2-8°C |
| solubility | 1 M NH4OH: soluble50mg/mL |
| form | Solid |
| pka | 6.77±0.10(Predicted) |
| color | White to Off-White |
| Water Solubility | 2.501g/L(25 ºC) |
| BRN | 127173 |
| CAS DataBase Reference | 1820-81-1(CAS DataBase Reference) |
| EPA Substance Registry System | 5-Chlorouracil (1820-81-1) |
Safety information for 5-Chlorouracil
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H341:Germ cell mutagenicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 5-Chlorouracil
| InChIKey | ZFTBZKVVGZNMJR-UHFFFAOYSA-N |
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