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HomeProduct name list5-METHYLCYTOSINE

5-METHYLCYTOSINE

  • CAS NO.:554-01-8
  • Empirical Formula: C5H7N3O
  • Molecular Weight: 125.13
  • MDL number: MFCD00233537
  • EINECS: 209-058-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 08:26:49
5-METHYLCYTOSINE Structural

What is 5-METHYLCYTOSINE?

Chemical properties

Crystals in prisms from water.

The Uses of 5-METHYLCYTOSINE

5-Methylcytosine is used as a marker to protect DNA from being cut by native methylation-sensitive restriction enzymes. It is also employed in the production of 4-amino-5-hydroxy-5-methyl-2-oxo-2,5-dihydro-imidazole-1-carbaldehyde.

Definition

ChEBI: A pyrimidine that is a derivative of cytosine, having a methyl group at the 5-position.

Purification Methods

Crystallise it from water (solubility is 3.4%). The hydrochloride has m 299-301o (sintering at 280o) (from aqueous HCl/Me2CO). [Hitchings et al. J Biol Chem 177 537 1949, Cohn J Am Chem Soc 73 1539 1951, Beilstein 25 II 183, 25 III/IV 3727.]

Properties of 5-METHYLCYTOSINE

Melting point: 270°C (rough estimate)
Boiling point: 232.57°C (rough estimate)
Density  1.2602 (rough estimate)
refractive index  1.6510 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  Methanol (Sparingly, Heated)
pka 9.05±0.10(Predicted)
form  Crystalline
color  White to Off-White
Water Solubility  Soluble in water.
Merck  14,6050
CAS DataBase Reference 554-01-8(CAS DataBase Reference)

Safety information for 5-METHYLCYTOSINE

Computed Descriptors for 5-METHYLCYTOSINE

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