5-Bromoisatoic anhydride

Synonym(s):6-Bromo-1,2-dihydro-4H-3,1-benzoxazine-2,4-dione

CAS NO.：4692-98-2
Empirical Formula: C8H4BrNO3
Molecular Weight: 242.03
MDL number: MFCD00016921
EINECS: 230-454-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-06 18:38:04

What is 5-Bromoisatoic anhydride?

Chemical properties

Off-white to salmon powder

The Uses of 5-Bromoisatoic anhydride

5-Bromoisatoic anhydride is an important chemical raw material and pharmaceutical intermediate, mainly used in laboratory research and development processes and chemical production processes.

Preparation

5-Bromoisatoic anhydride is prepared from 5-bromo indole by stirring in a 4:1 mixture of DMF/H2O for 16 h at room temperature.
1HNMR(DMSO-d6): δ 11.85 (s, br., 1H), 7.96 (dd, J = 0.8, 8.7 Hz, 1H), 7.87 (dd, J = 2.3, 8.7 Hz, 1H), 7.09 (dd, J = 8.8, 0.8 Hz, 1H).

Properties of 5-Bromoisatoic anhydride

Melting point:	280-285 °C (dec.) (lit.)
Density	1.826±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	soluble in Dimethylformamide
form	powder to crystal
pka	9.81±0.20(Predicted)
color	White to Light yellow to Light orange
CAS DataBase Reference	4692-98-2(CAS DataBase Reference)

Safety information for 5-Bromoisatoic anhydride

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H360:Reproductive toxicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention.