Isatoic Anhydride
Synonym(s):3,1-Benzoxazine-2,4(1H)-dione;Anthranilic acid N-carboxylic acid anhydride;Anthranilic acid N-carboxylic acid anhydride, 1,4-Dihydro-2H-3,1-benzoxazin-2,4-dione, 2H-3,1-Benzoxazine-2,4-(1H)-dione;Isatoic anhydride
- CAS NO.:118-48-9
- Empirical Formula: C8H5NO3
- Molecular Weight: 163.13
- MDL number: MFCD00006700
- EINECS: 204-255-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:09:03
What is Isatoic Anhydride?
Chemical properties
BEIGE TO BROWN POWDER
The Uses of Isatoic Anhydride
Isatoic anhydride is a potent inactivator of α-chymotrypsin and inactivates stoichiometrically. Isatoic Anhydride is an important compound in the preparation of serine protease inhibitors.
What are the applications of Application
Isatoic Anhydride is a potent inactivator of chymotrypsin
Definition
A bicyclic molecule composed of a benzene ring attached at the oand mpositions to a heterocyclic ring. It forms useful anthranilic acid derivatives by reaction with hydrogen.
Preparation
Phosphorus tribromide (0.035 mol) was added to a solution of N-carbethoxy- or N-carbobenzoxy-anthranilic acid (0.1 mol;prepared by coupling anthranilic acid with the corresponding carbalkoxy chloride in the usual way) in anhydrous diethyl ether (100 mL). After 24 h at room temperature, isatoic anhydride had separated as a microcrystalline product. It was collected by filtration, washed with dry diethyl ether, and recrystallized from ethanol. Yield ca. 90%.
Flammability and Explosibility
Non flammable
Purification Methods
Recrystallise it from EtOH or 95% EtOH (30mL/g) or dioxane (10mL/g) and dry it in a vacuum. [Wagner & Fegley Org Synth Coll Vol III 488 1955, Ben-Ishai & Katchalski J Am Chem Soc 74 3688 1952, UV: Zentmyer & Wagner J Org Chem 14 967 1949, Beilstein 27 II 299, 27III/IV 3330.]
Properties of Isatoic Anhydride
Melting point: | 233 °C (dec.) (lit.) |
Boiling point: | 290.19°C (rough estimate) |
Density | 1,52 g/cm3 |
vapor density | 5.6 (vs air) |
refractive index | 1.5510 (estimate) |
Flash point: | 308 °C |
storage temp. | Store below +30°C. |
solubility | 0.3g/l |
pka | 11.06±0.20(Predicted) |
form | Powder |
color | Beige to brown |
Water Solubility | decomposes |
Sensitive | Moisture Sensitive |
BRN | 136786 |
CAS DataBase Reference | 118-48-9(CAS DataBase Reference) |
NIST Chemistry Reference | Isatoic anhydride(118-48-9) |
EPA Substance Registry System | 2H-3,1-Benzoxazine-2,4(1H)-dione (118-48-9) |
Safety information for Isatoic Anhydride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H317:Sensitisation, Skin H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Isatoic Anhydride
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Moleculochem
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