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HomeProduct name listIsatoic Anhydride

Isatoic Anhydride

Synonym(s):3,1-Benzoxazine-2,4(1H)-dione;Anthranilic acid N-carboxylic acid anhydride;Anthranilic acid N-carboxylic acid anhydride, 1,4-Dihydro-2H-3,1-benzoxazin-2,4-dione, 2H-3,1-Benzoxazine-2,4-(1H)-dione;Isatoic anhydride

  • CAS NO.:118-48-9
  • Empirical Formula: C8H5NO3
  • Molecular Weight: 163.13
  • MDL number: MFCD00006700
  • EINECS: 204-255-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-11 14:08:43
Isatoic Anhydride Structural

What is Isatoic Anhydride?

Chemical properties

BEIGE TO BROWN POWDER

The Uses of Isatoic Anhydride

Isatoic anhydride is a potent inactivator of α-chymotrypsin and inactivates stoichiometrically. Isatoic Anhydride is an important compound in the preparation of serine protease inhibitors.

What are the applications of Application

Isatoic Anhydride is a potent inactivator of chymotrypsin

Definition

A bicyclic molecule composed of a benzene ring attached at the oand mpositions to a heterocyclic ring. It forms useful anthranilic acid derivatives by reaction with hydrogen.

Preparation

Phosphorus tribromide (0.035 mol) was added to a solution of N-carbethoxy- or N-carbobenzoxy-anthranilic acid (0.1 mol;prepared by coupling anthranilic acid with the corresponding carbalkoxy chloride in the usual way) in anhydrous diethyl ether (100 mL). After 24 h at room temperature, isatoic anhydride had separated as a microcrystalline product. It was collected by filtration, washed with dry diethyl ether, and recrystallized from ethanol. Yield ca. 90%.

Flammability and Explosibility

Non flammable

Purification Methods

Recrystallise it from EtOH or 95% EtOH (30mL/g) or dioxane (10mL/g) and dry it in a vacuum. [Wagner & Fegley Org Synth Coll Vol III 488 1955, Ben-Ishai & Katchalski J Am Chem Soc 74 3688 1952, UV: Zentmyer & Wagner J Org Chem 14 967 1949, Beilstein 27 II 299, 27III/IV 3330.]

Properties of Isatoic Anhydride

Melting point: 233 °C (dec.) (lit.)
Boiling point: 290.19°C (rough estimate)
Density  1,52 g/cm3
vapor density  5.6 (vs air)
refractive index  1.5510 (estimate)
Flash point: 308 °C
storage temp.  Store below +30°C.
solubility  0.3g/l
pka 11.06±0.20(Predicted)
form  Powder
color  Beige to brown
Water Solubility  decomposes
Sensitive  Moisture Sensitive
BRN  136786
CAS DataBase Reference 118-48-9(CAS DataBase Reference)
NIST Chemistry Reference Isatoic anhydride(118-48-9)
EPA Substance Registry System 2H-3,1-Benzoxazine-2,4(1H)-dione (118-48-9)

Safety information for Isatoic Anhydride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H317:Sensitisation, Skin
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P272:Contaminated work clothing should not be allowed out of the workplace.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Isatoic Anhydride

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