5-Bromoisatin
- CAS NO.:87-48-9
- Empirical Formula: C8H4BrNO2
- Molecular Weight: 226.03
- MDL number: MFCD00005719
- EINECS: 201-747-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:43
What is 5-Bromoisatin?
Chemical properties
Orange crystalline powder
The Uses of 5-Bromoisatin
5-Bromoisatin is used in the synthesis of N-derivatives of 5-bromoisatin, N-substituted pyrroles, linear polyaryleneoxindoles, 5-bromodioxindole, cinchoninic acid derivatives, 3-hydroxyoxindole, S-benzyldithiocarbazate Schiff Bases, 5-bromooxindole and Morita-Baylis-Hillman adducts of isatin derivatives. It is an indole derivative.
Definition
ChEBI: 5-Bromoisatin is a member of indoles. It has a role as an anticoronaviral agent.
Synthesis Reference(s)
Tetrahedron Letters, 25, p. 3099, 1984 DOI: 10.1016/0040-4039(84)80017-9
General Description
5-Bromoisatin is a 5-haloisatin. One of the methods reported for its synthesis is by reacting N-halosaccharins with isatin in the presence of SiO2. Its inotropic activity has been studied on rhythmically stimulated papillary muscles of guinea pigs. It is reported to exhibit analgesic and sedative properties at a dose of 0.2g/kg in mice.
Purification Methods
5-Bromoisatin forms red prisms or needles from EtOH. The N-acetate crystallises as yellow prisms from *C6H6, m 170-172o, and the N-methyl derivative forms orange-red needles from MeOH, m 172-173o. [Heller Chem Ber 53 1545 1920, Buu-Hoi Recl Trav Chim, Pays-Bas 73 197 1954, Baker etal. Tetrahedron Lett 215 1978, Beilstein 21 H 453, 21 III/IV 5009.]
Properties of 5-Bromoisatin
Melting point: | 247-252 °C (lit.) |
Density | 1.7498 (rough estimate) |
refractive index | 1.6120 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Soluble in N,N dimethylformamide. |
form | Crystalline Powder |
pka | 8.74±0.20(Predicted) |
color | Orange |
BRN | 383760 |
CAS DataBase Reference | 87-48-9(CAS DataBase Reference) |
Safety information for 5-Bromoisatin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Bromoisatin
InChIKey | MBVCESWADCIXJN-UHFFFAOYSA-N |
Abamectin manufacturer
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