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HomeProduct name list5-Bromoisatin

5-Bromoisatin

  • CAS NO.:87-48-9
  • Empirical Formula: C8H4BrNO2
  • Molecular Weight: 226.03
  • MDL number: MFCD00005719
  • EINECS: 201-747-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:43
5-Bromoisatin Structural

What is 5-Bromoisatin?

Chemical properties

Orange crystalline powder

The Uses of 5-Bromoisatin

5-Bromoisatin is used in the synthesis of N-derivatives of 5-bromoisatin, N-substituted pyrroles, linear polyaryleneoxindoles, 5-bromodioxindole, cinchoninic acid derivatives, 3-hydroxyoxindole, S-benzyldithiocarbazate Schiff Bases, 5-bromooxindole and Morita-Baylis-Hillman adducts of isatin derivatives. It is an indole derivative.

Definition

ChEBI: 5-Bromoisatin is a member of indoles. It has a role as an anticoronaviral agent.

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 3099, 1984 DOI: 10.1016/0040-4039(84)80017-9

General Description

5-Bromoisatin is a 5-haloisatin. One of the methods reported for its synthesis is by reacting N-halosaccharins with isatin in the presence of SiO2. Its inotropic activity has been studied on rhythmically stimulated papillary muscles of guinea pigs. It is reported to exhibit analgesic and sedative properties at a dose of 0.2g/kg in mice.

Purification Methods

5-Bromoisatin forms red prisms or needles from EtOH. The N-acetate crystallises as yellow prisms from *C6H6, m 170-172o, and the N-methyl derivative forms orange-red needles from MeOH, m 172-173o. [Heller Chem Ber 53 1545 1920, Buu-Hoi Recl Trav Chim, Pays-Bas 73 197 1954, Baker etal. Tetrahedron Lett 215 1978, Beilstein 21 H 453, 21 III/IV 5009.]

Properties of 5-Bromoisatin

Melting point: 247-252 °C (lit.)
Density  1.7498 (rough estimate)
refractive index  1.6120 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Soluble in N,N dimethylformamide.
form  Crystalline Powder
pka 8.74±0.20(Predicted)
color  Orange
BRN  383760
CAS DataBase Reference 87-48-9(CAS DataBase Reference)

Safety information for 5-Bromoisatin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 5-Bromoisatin

InChIKey MBVCESWADCIXJN-UHFFFAOYSA-N

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