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HomeProduct name list5-Benzyloxyindole

5-Benzyloxyindole

Synonym(s):NSC 62895

  • CAS NO.:1215-59-4
  • Empirical Formula: C15H13NO
  • Molecular Weight: 223.27
  • MDL number: MFCD00005676
  • EINECS: 214-930-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-06-06 16:20:44
5-Benzyloxyindole Structural

What is 5-Benzyloxyindole?

Chemical properties

Off-white to beige powder

The Uses of 5-Benzyloxyindole

5-Benzyloxyindole is used as reagent/reactant in regioselective preparation of CF3-β-tryptamine derivatives via base-free thermal ring-opening reaction of N-nosyl-2-CF3-aziridine with indoles.

The Uses of 5-Benzyloxyindole

Reactant in regio- and stereoselective morpholine-catalyzed direct C-3 alkenylation with α,β-unsaturated aldehydes Reactant in selective debenzylation of protective groups using SiliaCat-palladium under mild reaction conditions Reactant in metal-free Friedel-Crafts alkylation reactions Reactant in preparation of protein kinase (PKC) inhibitors Reactant in preparation of indole/quinoline carbothioic acid amide derivatives.

The Uses of 5-Benzyloxyindole

  • Reactant in regio- and stereoselective morpholine-catalyzed direct C-3 alkenylation with α,β-unsaturated aldehydes
  • Reactant in selective debenzylation of protective groups using SiliaCat-palladium under mild reaction conditions
  • Reactant in metal-free Friedel-Crafts alkylation reactions
  • Reactant in preparation of protein kinase (PKC) inhibitors
  • Reactant in preparation of indole/quinoline carbothioic acid amide derivatives

Purification Methods

It is recrystallised from *C6H6/pet ether or pet ether. The picrate forms red crystals from *C6H6 and has m 142-143o. [Burton & Leong Chem Ind (London) 1035 1953, Ek & Witkop J Am Chem Soc 76 5579 1954, fluorescence: Bridges & Williams Biochem J 107 225 1968, Beilstein 27 III/IV 1758.]

Properties of 5-Benzyloxyindole

Melting point: 100-104 °C (lit.)
Boiling point: 364.56°C (rough estimate)
Density  1.0707 (rough estimate)
refractive index  1.5500 (estimate)
storage temp.  2-8°C
solubility  ethanol: may be hazy yellow
pka 16.63±0.30(Predicted)
form  powder
color  white to light yellow
BRN  173532
Exposure limits ACGIH: TWA 20 ppm
OSHA: Ceiling 300 ppm; TWA 200 ppm
NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3)
CAS DataBase Reference 1215-59-4(CAS DataBase Reference)
NIST Chemistry Reference 1H-indole, 5-(phenylmethoxy)-(1215-59-4)

Safety information for 5-Benzyloxyindole

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H333:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H361:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 5-Benzyloxyindole

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