4-Methoxybenzylchloride
Synonym(s):4-(Chloromethyl)anisole
- CAS NO.：824-94-2
- Empirical Formula: C8H9ClO
- Molecular Weight: 156.61
- MDL number: MFCD00000915
- EINECS: 212-540-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-02-27 21:05:31
What is 4-Methoxybenzylchloride?
Chemical properties
Colorless liquid
The Uses of 4-Methoxybenzylchloride
O/N protecting group reagent which can be mildly oxidatively cleaved, e.g., with ceric ammonium nitrate.
What are the applications of Application
4-Methoxybenzyl chloride is a Suzuki cross-coupling reagent
Synthesis Reference(s)
Journal of Medicinal Chemistry, 20, p. 190, 1977 DOI: 10.1021/jm00212a002
The Journal of Organic Chemistry, 53, p. 3634, 1988 DOI: 10.1021/jo00250a048
General Description
4-Methoxybenzyl chloride undergoes mild oxidative claevage with ceric ammonium nitrate.
Purification Methods
Purify 4-anisyl chloride by fractional distillation under vacuum, and the middle fraction is redistilled at 10-6 mm at room temperature by intermittent cooling of the receiver in liquid N2, and the middle fraction is collected. [Mohammed & Kosower J Am Chem Soc 93 2709 1971, Beilstein 6 IV 2137.]
Properties of 4-Methoxybenzylchloride
| Melting point: | −1 °C(lit.) |
| Boiling point: | 117-118 °C14 mm Hg(lit.) |
| Density | 1.155 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 229 °F |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Liquid |
| color | Clear colorless to pale yellow |
| Water Solubility | slowly decomposes |
| Stability: | Moisture Sensitive |
| CAS DataBase Reference | 824-94-2(CAS DataBase Reference) |
| NIST Chemistry Reference | «alpha»-Chloro-4-methoxytoluene(824-94-2) |
Safety information for 4-Methoxybenzylchloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H290:Corrosive to Metals H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P234:Keep only in original container. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P390:Absorb spillage to prevent material damage. P405:Store locked up. P406:Store in corrosive resistant/… container with a resistant inner liner. P501:Dispose of contents/container to..… |
Computed Descriptors for 4-Methoxybenzylchloride
| InChIKey | MOHYOXXOKFQHDC-UHFFFAOYSA-N |
4-Methoxybenzylchloride manufacturer
ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED
2Y
Phone:+91-9966658228
Whatsapp: +91- 9966658228
product: 824-94-2 4-Methoxy Benzyl chloride, contains 1% potassium carbonate as stabilizer, 95% 99%
SUMUKHA LIFESCIENCES
2Y
Phone:+91-9000487488
Whatsapp: +91 9000487488
product: 4-Methoxybenzylchloride 98%
ASM Organics
Andhra Pradesh
Phone:91-9866122393
Whatsapp: 91-9866122393
product: 4-Methoxybenzyl chloride
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