4-Methoxybenzyl alcohol

Synonym(s):p-Anisyl alcohol;4-Methoxybenzyl alcohol;Anis alcohol;Anise alcohol

CAS NO.：105-13-5
Empirical Formula: C8H10O2
Molecular Weight: 138.16
MDL number: MFCD00004653
EINECS: 203-273-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-18 17:01:59

What is 4-Methoxybenzyl alcohol?

Chemical properties

Anise Alcohol occurs in vanilla pods and in anise seeds. It is a colorless liquid with a sweet, floral, slightly balsamic odor.
Insoluble in water, poorly soluble in Propylene glycol and Glycerin soluble in alcohol and oils.

Chemical properties

Anisyl alcohol has a floral odor with sweet, fruity (peach) taste.

Occurrence

Reported found in anise (Pimpinella anisum L.), honey, Bourbon vanilla (Vanilla planifolia Andrews), Tahiti vanilla (Vanilla tahitensis Moore), Illicium verum and tomato.

The Uses of 4-Methoxybenzyl alcohol

4-Methoxybenzyl Alcohol is used in the preparation of semiconductors, nanosheets and nanocrystals. Also is used as a reagent for various chemical organic reactions such as in the synthesis of quinolines. It is used as a fragrance and flavorant. It is used to study the photo catalytic oxidation of 4-methoxybenzyl alcohol to p-anisaldehyde.

Definition

ChEBI: 4-Methoxybenzyl alcohol is a member of benzyl alcohols.

Preparation

By reduction from anisic aldehyde

Taste threshold values

Taste characteristics at 10 ppm: spice, anise, vanilla, balsamic and powdery

Synthesis Reference(s)

Synthetic Communications, 18, p. 613, 1988 DOI: 10.1080/00397918808064019
Tetrahedron Letters, 32, p. 3243, 1991 DOI: 10.1016/S0040-4039(00)79734-6

General Description

Anisyl alcohol is a volatile aromatic compound mainly found in vanilla extracts and anise oil. It is used as a flavoring agent and fragrance ingredient.

Hazard

Extremely toxic.

Contact allergens

As a fragrance allergen, anisyl alcohol has to be mentioned by name in cosmetics within the EU.

Safety Profile

Moderately toxic by ingestion. A skin irritant. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also ALCOHOLS.

Properties of 4-Methoxybenzyl alcohol

Melting point:	22-25 °C (lit.)
Boiling point:	259 °C (lit.)
Density	1.113 g/mL at 25 °C (lit.)
vapor pressure	0.24-0.53Pa at 25℃
FEMA	2099 \| ANISYL ALCOHOL
refractive index	n20/D 1.544(lit.)
Flash point:	230 °F
storage temp.	-20°C
solubility	alcohol: freely soluble
form	Liquid After Melting
pka	14.43±0.10(Predicted)
Specific Gravity	1.108
color	Clear colorless to yellow
PH	6.3 (10g/l, H2O, 20℃)
Odor	at 100.00 %. sweet powdery hawthorn lilac rose floral hyacinth
explosive limit	0.9-7.3%(V)
Water Solubility	insoluble
Merck	14,665
JECFA Number	871
BRN	636654
CAS DataBase Reference	105-13-5(CAS DataBase Reference)
NIST Chemistry Reference	Benzenemethanol, 4-methoxy-(105-13-5)
EPA Substance Registry System	4-Methoxybenzenemethanol (105-13-5)

Safety information for 4-Methoxybenzyl alcohol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.