4-Benzyloxyindole
Synonym(s):NSC 92539
- CAS NO.:20289-26-3
- Empirical Formula: C15H13NO
- Molecular Weight: 223.27
- MDL number: MFCD00047200
- EINECS: 243-690-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-17 18:24:26
What is 4-Benzyloxyindole?
Chemical properties
Off-White Crystalline Solid with Few Darker (Brown) Particles
The Uses of 4-Benzyloxyindole
4-Benzyloxyindole was used in the synthesis of 4-alkyloxy-aminoalkyl indole derivatives.
The Uses of 4-Benzyloxyindole
Indole derivative as substrate-binding; N297Q and I300V mutants of cytochrome P 450 2A6 display expansion of substrate specificity of cytochrome P 450 2A6 to oxidize substituted indoles
Reactions
4-Benzyloxyindole was used in the synthesis of 4-alkyloxy-aminoalkyl indole derivatives.
- Reactant for regioselective synthesis of oxopyrrolidine analogs via iodine-catalyzed Markovnikov addition
- Reactant for preparation of indoles by Bartoli reductive cyclization as useful intermediates in medicinal chemistry research
- Reactant for synthesis of carbon-11-labeled 4-aryl-4H-chromenes as new PET agents for imaging of apoptosis in cancer
- Reactant for preparation of HCV inhibitors.
- Reactant for preparation of indol-3-yl tetramethylcyclopropyl ketones as CB2 cannabinoid receptor ligands
- Reactant for preparation of 4-aryl-4H-chromenes as apoptosis inducers
Synthesis Reference(s)
Organic Syntheses, Coll. Vol. 7, p. 34, 1990
The Journal of Organic Chemistry, 51, p. 4294, 1986 DOI: 10.1021/jo00372a037
Tetrahedron Letters, 24, p. 4561, 1983 DOI: 10.1016/S0040-4039(00)85955-9
Properties of 4-Benzyloxyindole
Melting point: | 57-61 °C (lit.) |
Boiling point: | 364.56°C (rough estimate) |
Density | 1.0707 (rough estimate) |
refractive index | 1.5500 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
pka | 17.17±0.30(Predicted) |
form | Solid |
color | Beige to Brown |
BRN | 183150 |
CAS DataBase Reference | 20289-26-3(CAS DataBase Reference) |
Safety information for 4-Benzyloxyindole
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Benzyloxyindole
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
5-Benzyloxyindole
4-Methoxybenzylchloride
Indole-3-butyric acid
Indole
Indometacin
Indole-3-acetic acid
4-Benzyloxyindole
4-Benzyloxyindole-3-carboxaldehyde 98%
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