5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

CAS NO.：330792-70-6
Empirical Formula: C16H12N4O
Molecular Weight: 276.29
MDL number: MFCD20270361
EINECS: 805-642-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-13 21:11:14

What is 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile?

Chemical properties

Light yellow to off-white powder.

The Uses of 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole has been used as a reactant in the preparation of ring-fused pyrazole derivatives to be used a inhibitors of lymphocyte-specific kinase (Lck)

What are the applications of Application

5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile is an intermediate of Ibrutinib (PCI-32765). it is a heterocyclic intermediate that typically used in the preparation of ACP-196, a selective second-generation BTK inhibitor.

Properties of 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

Boiling point:	585.3±50.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
refractive index	1.699
Flash point:	307.8℃
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly)
pka	10.83±0.50(Predicted)
InChI	InChI=1S/C16H12N4O/c17-10-14-15(19-20-16(14)18)11-6-8-13(9-7-11)21-12-4-2-1-3-5-12/h1-9H,(H3,18,19,20)

Safety information for 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.