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HomeProduct name listChloropretadalafil

Chloropretadalafil

Chloropretadalafil Structural

What is Chloropretadalafil?

Description

Chloropretadalafil is a key synthetic intermediate of tadalafil which is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).

Chemical properties

White Solid

The Uses of Chloropretadalafil

(1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(chloroacetyl)-2,3,4,9- tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic is used as an intermediate in the synthesis of Tadafil, which is used for the treatment of erectile dysfunction.

What are the applications of Application

Chloropretadalafil is an intermediate in the production of Tadalafil

References

[1] ALAIN DAUGAN. The Discovery of Tadalafil: A Novel and Highly Selective PDE5 Inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1‘,2‘:1,6]pyrido[3,4-b]indole-1,4-dione Analogues[J]. Journal of Medicinal Chemistry, 2003. DOI:10.1021/jm0300577.
[2] SHI X X, LIU S, XU W Z, et al. Highly stereoselective Pictet–Spengler reaction of d-tryptophan methyl ester with piperonal: convenient syntheses of Cialis (Tadalafil), 12a-epi-Cialis, and their deuterated analogues[J]. Tetrahedron-asymmetry, 2008, 19: 435-442. DOI:10.1016/J.TETASY.2007.12.017.
[3] ZHANG Y, HE Q, DING H, et al. IMPROVED SYNTHESIS OF TADALAFIL[J]. Organic Preparations and Procedures International, 2005, 37: 102-199. DOI:10.1080/00304940509355408.

Properties of Chloropretadalafil

Melting point: 230-232℃
Boiling point: 627.5±55.0 °C(Predicted)
Density  1.445
storage temp.  Inert atmosphere,2-8°C
solubility  Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form  Solid
pka 16.25±0.60(Predicted)
color  White to Pale Orange
InChI InChI=1S/C22H19ClN2O5/c1-28-22(27)16-9-14-13-4-2-3-5-15(13)24-20(14)21(25(16)19(26)10-23)12-6-7-17-18(8-12)30-11-29-17/h2-8,16,21,24H,9-11H2,1H3/t16-,21-/m1/s1

Safety information for Chloropretadalafil

Computed Descriptors for Chloropretadalafil

InChIKey JUKHNCNDFOAFLT-IIBYNOLFSA-N
SMILES N1C2=C(C=CC=C2)C2C[C@H](C(OC)=O)N(C(CCl)=O)[C@H](C3=CC=C4OCOC4=C3)C1=2

Abamectin manufacturer

Ultratech India Ltd

1Y
Phone:+91-2266444000
product: (1R,3R)-Methyl 1-(1,3-benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylate 171489-59-1 98%
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Rivashaa Agrotech Biopharma Pvt. Ltd.

1Y
Phone:+91-7926462688
product: 171489-59-1 (1R,3R)-Methyl 1-(1,3-benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylate 98%
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Cubane Pharmaceuticals LLP

1Y
Phone:+91-9825323764
Whatsapp: +91-9825323764
product: 171489-59-1 99%
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Scinva Chemicals and Pharmaceuticals Pvt Ltd

1Y
Phone:+917406196725
Whatsapp: +91-7406196725
product: (1R,3R)-Methyl 1-(1,3-benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylate 98%
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Apiqule Pharmachem LLP

1Y
Phone:+91-9904897541
Whatsapp: +91-9904897541
product: (1R,3R)-Methyl 1-(1,3-benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylate 99%
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