5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
- CAS NO.：6981-18-6
- Empirical Formula: C14H18N4O2
- Molecular Weight: 274.32
- MDL number: MFCD00057747
- EINECS: 230-246-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine?
The Uses of 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial.
The Uses of 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial.This compound is a contaminant of emerging concern (CECs).
Definition
ChEBI: 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine is a dimethoxybenzene.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 14, p. 462, 1971 DOI: 10.1021/jm00287a029
Properties of 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
| Melting point: | 231.0 to 235.0 °C |
| Boiling point: | 521.5±60.0 °C(Predicted) |
| Density | 1.223±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 7.11±0.10(Predicted) |
| color | Off-White |
| Water Solubility | Water: Insoluble |
| λmax | 287nm(CHCl3)(lit.) |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 6981-18-6(CAS DataBase Reference) |
| EPA Substance Registry System | Ormetoprim (6981-18-6) |
Safety information for 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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