Tetramethylammonium chloride

Synonym(s):Tetramethylammonium chloride;TMA

CAS NO.：75-57-0
Empirical Formula: C4H12ClN
Molecular Weight: 109.6
MDL number: MFCD00011628
EINECS: 200-880-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-30 18:52:02

What is Tetramethylammonium chloride?

Chemical properties

white crystals

The Uses of Tetramethylammonium chloride

Chemical intermediate, catalyst, inhibitor.
Tetramethylammonium chloride

The Uses of Tetramethylammonium chloride

Tetramethylammonium chloride along with N-hydroxyphthalimide and xanthone may be used as an efficient chloride catalytic system for the aerobic oxidation of hydrocarbons to form the corresponding oxygenated compounds. It may also be used as a phase transfer catalyst for the synthesis of aryl fluorides via selective chloride/fluoride exchange reaction of activated aryl chlorides with potassium fluoride in solid-liquid phase.

The Uses of Tetramethylammonium chloride

TMAC may be used in ion-exchange procedures to show the increase of pH in understanding the chemical behaviour of catalyst [CTA]Si-MCM-41 using Knoevenagel condensation model.

Definition

ChEBI: N,N,N-Trimethylmethanaminium chloride is an organic molecular entity.

General Description

Tetramethylammonium chloride is a quaternary ammonium salt commonly used as a catalyst due to its thermal stability and also tolerance towards strong aqueous bases or nucleophiles.

Safety Profile

Poison by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NOx, NH3, and Cl-. See also CHLORIDES.

Purification Methods

Crystallise the chloride from EtOH, EtOH/CHCl3, EtOH/diethyl ether, acetone/EtOH (1:1), isopropanol or water. Traces of the free amine can be removed by washing with CHCl3. [Beilstein 4 IV 145.]

Properties of Tetramethylammonium chloride

Melting point:	>300 °C (lit.)
Boiling point:	165.26°C (rough estimate)
Density	1,17 g/cm³
refractive index	1.5320 (estimate)
storage temp.	Store below +30°C.
solubility	methanol: 0.1 g/mL, clear, colorless
form	Hygroscopic Crystalline Powder
color	White to ivory
Specific Gravity	1.169
PH Range	6 - 8
PH	6-8 (100g/l, H2O, 20℃)
Odor	Odorless
Water Solubility	>60 g/100 mL (20 ºC)
Sensitive	Hygroscopic
λmax	λ: 260 nm Amax: 0.02 λ: 280 nm Amax: 0.02
BRN	2496575
Stability:	Stable. Incompatible with strong oxidizing agents, water. Hygroscopic.
CAS DataBase Reference	75-57-0(CAS DataBase Reference)
NIST Chemistry Reference	Tetramethylammonium chloride(75-57-0)
EPA Substance Registry System	Tetramethylammonium chloride (75-57-0)

Safety information for Tetramethylammonium chloride

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H300:Acute toxicity,oral H311:Acute toxicity,dermal H315:Skin corrosion/irritation H370:Specific target organ toxicity, single exposure H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.