QX-314
Synonym(s):N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide;QX-314;QX-314 - CAS 21306-56-9 - Calbiochem
- CAS NO.:21306-56-9
- Empirical Formula: C16H27N2O+
- Molecular Weight: 263.4
- MDL number: MFCD00083182
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is QX-314?
The Uses of QX-314
QX-314 bromide is a derivative of Lidocaine. It is a local anesthetic.
The Uses of QX-314
Blocker of voltage-activated sodium channels
What are the applications of Application
QX-314 is a sodium channel protein inhibitor
Biological Activity
Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.
Properties of QX-314
Melting point: | 220 - 222°C |
storage temp. | Desiccate at RT |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | neat |
color | White to Off-White |
Specific Activity | 40-60 Ci/mmol |
Solvent | Ethanol:water (1:1) |
Concentration | 1 mCi/ml |
Safety information for QX-314
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for QX-314
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
BATRACHOTOXIN
L-KAWAIN
TETRODOTOXIN
VERATRIDINE
Aconitine
Tetracaine hydrochloride
PD 85639
MONOETHYLGLYCINEXYLIDIDE
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