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HomeProduct name listQX-314

QX-314

Synonym(s):N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide;QX-314;QX-314 - CAS 21306-56-9 - Calbiochem

QX-314 Structural

What is QX-314?

The Uses of QX-314

QX-314 bromide is a derivative of Lidocaine. It is a local anesthetic.

The Uses of QX-314

Blocker of voltage-activated sodium channels

What are the applications of Application

QX-314 is a sodium channel protein inhibitor

Biological Activity

Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.

Properties of QX-314

Melting point: 220 - 222°C
storage temp.  Desiccate at RT
solubility  DMSO (Slightly), Methanol (Slightly)
form  neat
color  White to Off-White
Specific Activity 40-60 Ci/mmol
Solvent Ethanol:water (1:1)
Concentration 1 mCi/ml

Safety information for QX-314

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for QX-314

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