4-Trifluoromethoxyphenylboronic acid
Synonym(s):4-(Trifluoromethoxy)benzeneboronic acid
- CAS NO.：139301-27-2
- Empirical Formula: C7H6BF3O3
- Molecular Weight: 205.93
- MDL number: MFCD01074648
- EINECS: 000-000-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 13:32:20
What is 4-Trifluoromethoxyphenylboronic acid?
Chemical properties
white to beige crystalline powder
The Uses of 4-Trifluoromethoxyphenylboronic acid
B-[4-(Trifluoromethoxy)phenyl]boronic Acid is a reagent used in the synthesis of orally bioavailable matrix metalloprotinase inhibitors. Also used in the preparation of chromen-4-one inhibitors used against DNA dependant protein kinases.
What are the applications of Application
4-Trifluoromethoxyphenylboronic acid can reactant involved in the synthesis of biologically active molecules including:
Lactate dehydrogenase inhibitors for use against cancer cell proliferation
Nitro-phenoxybenzoic acid derivatives for PAI-1 inhibition
PA-824 analogs for use as antituberculosis drugs
Modulators of survival motor neuron protein
Reactant involved in addition reactions and cross-coupling reactions including Suzuki-Miyaura cross-coupling
Properties of 4-Trifluoromethoxyphenylboronic acid
| Melting point: | 123-127 °C(lit.) |
| Boiling point: | 256.6±50.0 °C(Predicted) |
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | Crystalline Powder |
| pka | 8.29±0.10(Predicted) |
| color | White to beige |
| BRN | 8548201 |
| CAS DataBase Reference | 139301-27-2(CAS DataBase Reference) |
Safety information for 4-Trifluoromethoxyphenylboronic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 4-Trifluoromethoxyphenylboronic acid
| InChIKey | HUOFUOCSQCYFPW-UHFFFAOYSA-N |
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