4-Pyrrolidinopyridine
- CAS NO.:2456-81-7
- Empirical Formula: C9H12N2
- Molecular Weight: 148.21
- MDL number: MFCD00006415
- EINECS: 219-534-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-27 16:27:43
What is 4-Pyrrolidinopyridine?
Description
4-Pyrrolidinopyridine is the pyridine derivative. It can be used as catalyst employed in polymerization reactions or Hypernucleophilic acylation catalyst. For example, it can be used as the catalyst for the geometry-selective (E-selective) acylation of tetrasubstituted α, α'-alkenediols. It can also be used as the ligand in metal complexes such as the Chloride and pseudohalide hydride-carbonyl ruthenium(II) complexes.
Chemical properties
white to light brown crystalline mass
The Uses of 4-Pyrrolidinopyridine
Catalyst employed in polymerization reactions. Ligand in metal complexes.
Synthesis Reference(s)
Synthetic Communications, 9, p. 251, 1979 DOI: 10.1080/00397917908064147
Synthesis, p. 985, 1988 DOI: 10.1055/s-1988-27777
References
http://www.sigmaaldrich.com/catalog/product/aldrich/213373?lang=en®ion=US
http://www.sigmaaldrich.com/catalog/product/sial/83275?lang=en®ion=US
Yamanaka M et al. "Origin of High E -Selectivity in 4-Pyrrolidinopyridine-Catalyzed Tetrasubstituted α,α′-Alkenediol: A Computational and Experimental Study." Journal of Organic Chemistry 80.6(2015):3075-82.
J. G. Ma?ecki, and A. Maroń. "Chloride and pseudohalide hydride-carbonyl ruthenium(II) complexes with 4-pyrrolidinopyridine as co-ligand."Transition Metal Chemistry 38.2(2013):133-142.
Properties of 4-Pyrrolidinopyridine
Melting point: | 54-58 °C(lit.) |
Boiling point: | 171-173 °C (20.2527 mmHg) |
Density | 1.0628 (rough estimate) |
refractive index | 1.5378 (estimate) |
Flash point: | >230 °F |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | methanol: 0.1 g/mL, clear |
form | Crystalline Mass, Crystals and/or Chunks |
pka | 9.58±0.10(Predicted) |
color | White to yellow to light brown |
PH | 10.5 (3g/l, H2O, 21℃) |
Water Solubility | 3 g/L (21 ºC) |
BRN | 472443 |
CAS DataBase Reference | 2456-81-7(CAS DataBase Reference) |
Safety information for 4-Pyrrolidinopyridine
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Pyrrolidinopyridine
InChIKey | RGUKYNXWOWSRET-UHFFFAOYSA-N |
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