mycotrienin II
- CAS NO.:82189-04-6
- Empirical Formula: C36H50N2O8
- Molecular Weight: 638.79
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:07
What is mycotrienin II?
Description
Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1 expression induced by pro-inflammatory cytokines.4
The Uses of mycotrienin II
Ansatrienin B, also known as Mycotrienin II and Antibiotic T 23II, was isolated from a Streptomyces sp.. Closely related to the cytotrienins and trienomycins, it displays potent activity against tumour cell lines and inhibits osteoclastic bone resorption. Ansatrienin B also significantly potentiates the action of several clinical anti-cancer agents.
What are the applications of Application
Ansatrienin B is an ansamycin antibiotic that contains a triene structure
References
1) Sugita et al. (1982), Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II; J. Antibiot. (Tokyo), 35 1467 2) Feuerbach et al. (1995), Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption; J. Biol. Chem., 270 25949 3) Yamada et al. (2011), Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokines; J. Antibiot. (Tokyo), 64 361
Properties of mycotrienin II
storage temp. | -20°C |
solubility | Soluble in DMSO, DMF, Ethanol or Methanol |
form | solid |
color | Pale-yellow |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol, or methanol may be stored at -20°C for up to 3 months. |
Safety information for mycotrienin II
Computed Descriptors for mycotrienin II
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