SU 4312
Synonym(s):3-(4-Dimethylaminobenzylidenyl)-2-indolinone;3-[[(4-Dimethyl-amino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture
- CAS NO.:5812-07-7
- Empirical Formula: C17H16N2O
- Molecular Weight: 264.32
- MDL number: MFCD00118147
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-09 19:38:33
What is SU 4312?
Description
SU-4312 (5812-07-7) is a potent selective inhibitor of VEGFR kinase (also known as Flk-1 and KDR). Inhibition of the activated kinase (IC50 = 0.4 μM) is 100-fold less than inhibition of the unactivated kinase (IC50 = 0.04 μM). SU-4312 also inhibits PDGFR kinase (IC50 = 19.4 μM).
The Uses of SU 4312
SU 4312 is a vascular endothelial growth factor receptor KDR tyrosine kinase antagonist.
What are the applications of Application
SU 4312 is a potent and selective VEGFR (Flk/Flt) inhibitor
Definition
ChEBI: A member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein yrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.
Biological Activity
Potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC 50 values are 0.8 and 19.4 mM respectively). Selective over EGFR and c-Src tyrosine kinases.
References
1) Kendall et al. (1999), Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues; J. Biol. Chem., 274 6453 2) Sun et al. (1998), Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases; J. Med. Chem., 41 2588
Properties of SU 4312
Melting point: | 225-232 °C |
Boiling point: | 497.1±45.0 °C(Predicted) |
Density | 1.219±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: 30 mg/mL |
form | Orange solid. |
pka | 12.89±0.20(Predicted) |
color | orange |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Safety information for SU 4312
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for SU 4312
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