4-Nitrophenyl chloroformate
Synonym(s):4-Nitrophenyl chlorocarbonate, Chloroformic acid 4-nitrophenyl ester;4-Nitrophenyl chloroformate;Chloroformic acid 4-nitrophenyl ester
- CAS NO.:7693-46-1
- Empirical Formula: C7H4ClNO4
- Molecular Weight: 201.56
- MDL number: MFCD00007321
- EINECS: 231-706-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-12-25 13:23:17
What is 4-Nitrophenyl chloroformate?
Chemical properties
Cream solid
The Uses of 4-Nitrophenyl chloroformate
4-Nitrophenyl Chloroformate is an ester of chloroformic acid used in the immobilization of enzymes and other biomolecules.
The Uses of 4-Nitrophenyl chloroformate
4-Nitrophenyl chloroformate is used in the synthesis of poly(oxyethylene) modified dextrans. It is also used to prepare a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA. Further, it is used in the synthesis of mixed, activated carbonates, thiocarbonates and activated urethanes. In addition to this, it is used in the preparation of 4-nitrophenyl diazoacetate with diazomethane.
The Uses of 4-Nitrophenyl chloroformate
4-Nitrophenyl chloroformate can be used:
- As a reagent for the activation of amines, alcohols and thiols.
- In the synthesis of 4-substituted phenyl derivatives of 1,2,4-triazolidindiones (urazoles).
- In the solid-phase synthesis of 3-aryl-2,4-quinazolinedione derivatives with potent anti-cancer property.
- In the preparation of poly(oxyethylene) modified dextrans.
- To synthesize a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA.
What are the applications of Application
4-Nitrophenyl chloroformate is a zero length crosslinker
Properties of 4-Nitrophenyl chloroformate
Melting point: | 77-79 °C(lit.) |
Boiling point: | 159-162 °C19 mm Hg(lit.) |
Density | 1.5719 (rough estimate) |
refractive index | 1.6000 (estimate) |
Flash point: | >110°C |
storage temp. | 2-8°C |
solubility | Soluble in acetone, chloroform, acetone, toluene and benzene. |
form | isopropanol suspension |
color | White to yellow-beige |
Water Solubility | decomposes |
Sensitive | Lachrymatory |
BRN | 518127 |
Stability: | Stable. Incompatible with strong bases, acids. Combustible. |
CAS DataBase Reference | 7693-46-1(CAS DataBase Reference) |
NIST Chemistry Reference | Carbonochloridic acid, 4-nitrophenyl ester(7693-46-1) |
EPA Substance Registry System | Carbonochloridic acid, 4-nitrophenyl ester (7693-46-1) |
Safety information for 4-Nitrophenyl chloroformate
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H314:Skin corrosion/irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Nitrophenyl chloroformate
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