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HomeProduct name list4-Nitrophenyl chloroformate

4-Nitrophenyl chloroformate

Synonym(s):4-Nitrophenyl chlorocarbonate, Chloroformic acid 4-nitrophenyl ester;4-Nitrophenyl chloroformate;Chloroformic acid 4-nitrophenyl ester

  • CAS NO.:7693-46-1
  • Empirical Formula: C7H4ClNO4
  • Molecular Weight: 201.56
  • MDL number: MFCD00007321
  • EINECS: 231-706-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-12-25 13:23:17
4-Nitrophenyl chloroformate Structural

What is 4-Nitrophenyl chloroformate?

Chemical properties

Cream solid

The Uses of 4-Nitrophenyl chloroformate

4-Nitrophenyl Chloroformate is an ester of chloroformic acid used in the immobilization of enzymes and other biomolecules.

The Uses of 4-Nitrophenyl chloroformate

4-Nitrophenyl chloroformate is used in the synthesis of poly(oxyethylene) modified dextrans. It is also used to prepare a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA. Further, it is used in the synthesis of mixed, activated carbonates, thiocarbonates and activated urethanes. In addition to this, it is used in the preparation of 4-nitrophenyl diazoacetate with diazomethane.

The Uses of 4-Nitrophenyl chloroformate

4-Nitrophenyl chloroformate can be used:

  • As a reagent for the activation of amines, alcohols and thiols.
  • In the synthesis of 4-substituted phenyl derivatives of 1,2,4-triazolidindiones (urazoles).
  • In the solid-phase synthesis of 3-aryl-2,4-quinazolinedione derivatives with potent anti-cancer property.
  • In the preparation of poly(oxyethylene) modified dextrans.
  • To synthesize a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA.

What are the applications of Application

4-Nitrophenyl chloroformate is a zero length crosslinker

Properties of 4-Nitrophenyl chloroformate

Melting point: 77-79 °C(lit.)
Boiling point: 159-162 °C19 mm Hg(lit.)
Density  1.5719 (rough estimate)
refractive index  1.6000 (estimate)
Flash point: >110°C
storage temp.  2-8°C
solubility  Soluble in acetone, chloroform, acetone, toluene and benzene.
form  isopropanol suspension
color  White to yellow-beige
Water Solubility  decomposes
Sensitive  Lachrymatory
BRN  518127
Stability: Stable. Incompatible with strong bases, acids. Combustible.
CAS DataBase Reference 7693-46-1(CAS DataBase Reference)
NIST Chemistry Reference Carbonochloridic acid, 4-nitrophenyl ester(7693-46-1)
EPA Substance Registry System Carbonochloridic acid, 4-nitrophenyl ester (7693-46-1)

Safety information for 4-Nitrophenyl chloroformate

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H314:Skin corrosion/irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-Nitrophenyl chloroformate

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