4-Methylsulfonylaniline

CAS NO.：5470-49-5
Empirical Formula: C7H9NO2S
Molecular Weight: 171.22
MDL number: MFCD00025353
EINECS: 226-803-8
SAFETY DATA SHEET (SDS)
Update Date: 2023-09-04 17:31:24

What is 4-Methylsulfonylaniline?

The Uses of 4-Methylsulfonylaniline

It is used as pharmaceutical intermediate. A series of 4-(methylsulfonyl)aniline derivatives were synthesized in order to obtain new compounds as a potential anti-inflammatory agents with expected selectivity against COX-2 enzyme.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 7867, 1994 DOI: 10.1016/0040-4039(94)80139-8

Properties of 4-Methylsulfonylaniline

Melting point:	243-245°C
Boiling point:	384.3±34.0 °C(Predicted)
Density	1.44
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly, Sonicated), Ethyl Acetate (Slightly, Sonicated)
form	Crystalline Powder
pka	pK1:1.48(+1) (25°C)
color	White
Water Solubility	Soluble in water.
Sensitive	Light Sensitive
CAS DataBase Reference	5470-49-5(CAS DataBase Reference)
NIST Chemistry Reference	4-Aminophenyl methyl sufhone(5470-49-5)

Safety information for 4-Methylsulfonylaniline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.