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HomeProduct name list4-Methoxypyridine

4-Methoxypyridine

  • CAS NO.:620-08-6
  • Empirical Formula: C6H7NO
  • Molecular Weight: 109.13
  • MDL number: MFCD00674049
  • EINECS: 210-624-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-06-05 17:10:12
4-Methoxypyridine Structural

What is 4-Methoxypyridine?

Chemical properties

clear colorless to slightly yellow liquid

The Uses of 4-Methoxypyridine

4-Methoxypyridine, is used as a building block for the synthesis of some biologically active compounds. It is used for the preparation of a new series of benzoylated N-ylides as protein farnesyltransferase inhibitors.

The Uses of 4-Methoxypyridine

4-Methoxypyridine was used as a starting reagent for the stereocontrolled synthesis of (±)-pumiliotoxin C and (±)-lasubine II. It was also used in an efficient construction of dihyropyridin-4-ones, which serves as potential ligands for neuronal nicotinic acetycholine receptors.

General Description

4-Methoxypyridine has been prepared from 4-methoxypyridine-N-oxide, via catalytic hydrogenation. Ortho lithiation of 4-methoxypyridine using mesityllithium as the metalating base has been studied.

Properties of 4-Methoxypyridine

Melting point: 4 °C
Boiling point: 108-111 °C/65 mmHg (lit.)
Density  1.075 g/mL at 25 °C (lit.)
refractive index  1.518-1.522
Flash point: 74 °C
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  DMSO (Slightly), Methanol (Slightly)
form  Liquid
pka 6.58(at 25℃)
Specific Gravity 1.075
color  Clear colorless to slightly yellow
BRN  108211
CAS DataBase Reference 620-08-6(CAS DataBase Reference)
NIST Chemistry Reference Pyridine, 4-methoxy-(620-08-6)

Safety information for 4-Methoxypyridine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-Methoxypyridine

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