4-Ethoxyphenol

Synonym(s):Hydroquinone monoethyl ether

CAS NO.：622-62-8
Empirical Formula: C8H10O2
Molecular Weight: 138.16
MDL number: MFCD00002334
EINECS: 210-748-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-01-16 16:12:45

What is 4-Ethoxyphenol?

Chemical properties

beige crystalline powder or chunks

Chemical properties

Hydroquinone monoethyl ether has a sweet herbaceous odor, which is reminiscent of anise and fennel

The Uses of 4-Ethoxyphenol

4-Ethoxyphenol has been used as substrate to evaluate kinetic constant for the monophenolase activity of mushroom tyrosinase.

The Uses of 4-Ethoxyphenol

Intermediates of Liquid Crystals

Definition

ChEBI: 4-Ethoxyphenol is a member of phenols and an aromatic ether.

Preparation

Hydroquinone monoethyl ether is produced by regulated (Mono)-ethylation of Hydroquinone with Diethylsulfate in weak aqueous alkaline solution.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 8727, 1994 DOI: 10.1016/S0040-4039(00)78482-6

General Description

4-Ethoxyphenol is the major dehalogenated product formed during H₂O₂-driven microperoxidase-8-catalyzed dehalogenation of 4-fluorophenol.

Safety Profile

Poison by intraperitoneal route. Experimentalreproductive effects. An irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Solubility in organics

Soluble in alcohol and oils. Fairly soluble in Propylene glycol.

Properties of 4-Ethoxyphenol

Melting point:	64-67 °C
Boiling point:	131 °C (9 mmHg)
Density	1.0742 (rough estimate)
refractive index	1.5231 (estimate)
FEMA	3695 \| HYDROQUINONE MONOETHYL ETHER
Flash point:	121°C/9mm
storage temp.	Inert atmosphere,Room Temperature
solubility	almost transparency in Methanol
pka	10.44±0.13(Predicted)
form	Crystalline Powder or Chunks
color	Beige
Odor	at 10.00 % in dipropylene glycol. mild hawthorn phenolic plastic nutty
Water Solubility	slightly soluble
JECFA Number	720
BRN	1907114
CAS DataBase Reference	622-62-8(CAS DataBase Reference)
NIST Chemistry Reference	4-Ethoxyphenol(622-62-8)
EPA Substance Registry System	Phenol, 4-ethoxy- (622-62-8)

Safety information for 4-Ethoxyphenol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.