4-(Dimethylamino)benzophenone

Synonym(s):p -Benzoyl-N ,N -dimethylaniline;4-Benzoyl-N ,N -dimethylaniline

CAS NO.：530-44-9
Empirical Formula: C15H15NO
Molecular Weight: 225.29
MDL number: MFCD00008311
EINECS: 208-478-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:15:32

4-(Dimethylamino)benzophenone Structural

What is 4-(Dimethylamino)benzophenone?

Chemical properties

YELLOW CRYSTALLINE POWDER OR CRYSTALS

The Uses of 4-(Dimethylamino)benzophenone

4-(Dimethylamino)benzophenone is an important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.

Synthesis Reference(s)

Synthesis, p. 544, 1986 DOI: 10.1055/s-1986-31696
Tetrahedron Letters, 34, p. 7595, 1993 DOI: 10.1016/S0040-4039(00)60409-4

Purification Methods

Crystallise the pale green p-dimethylaminobenzophenone from EtOH. Dissolve 100g in 600mL of boiling EtOH, add 5g of charcoal, cool, isolate the solid by centrifugation and similarly wash the pale crystals with ice-cold EtOH. When filtered by suction, EtOH solution remains on the crystals and turns deep green in air. Dry it in a vacuum and store it in the dark. The hydrazone has m 128-130o and forms a ketyl with potassium. [Hurd & Webb Org Synth Coll Vol I 217 1941, Beilstein 14 H 82, 14 I 288, 14 III 218, 14 IV 248.]

Properties of 4-(Dimethylamino)benzophenone

Melting point:	88-90 °C(lit.)
Boiling point:	250 °C / 15mmHg
Density	1.0463 (rough estimate)
refractive index	1.5200 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	powder to crystal
pka	2.12±0.12(Predicted)
color	White to Light yellow to Green
Water Solubility	insoluble
Merck	14,3233
CAS DataBase Reference	530-44-9(CAS DataBase Reference)
NIST Chemistry Reference	Methanone, [4-(dimethylamino)phenyl]phenyl-(530-44-9)
EPA Substance Registry System	Methanone, [4-(dimethylamino)phenyl]phenyl- (530-44-9)

Safety information for 4-(Dimethylamino)benzophenone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.