2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
Synonym(s):5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid;HMBS;Sulisobenzone
- CAS NO.:4065-45-6
- Empirical Formula: C14H12O6S
- Molecular Weight: 308.31
- MDL number: MFCD00024962
- EINECS: 223-772-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid?
Chemical properties
white to yellowish powder
Originator
Uval,Dome,US,1965
The Uses of 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is a commonly used, FDA approved sunscreen chemical with uVA-absorbing properties and an approved usage level of 5 to 10 percent. It protects a formulation from the effects of uV-light exposure.
The Uses of 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
Ultraviolet absorber for leather and textile fibers; in cosmetics and shampoos.
The Uses of 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
sulisobenzone is the drug name for benzophenone-4, a sunscreen chemical.
Definition
ChEBI: Sulisobenzone is a member of benzophenones.
Manufacturing Process
663 g of dichloroethane and 74.6 g 2-hydroxy-4-methoxybenzophenone were charged into a 3-neck flask equipped with stirrer, thermometer, reflux condenser and dropping funnel and a heating mantle. The solution was heated to the reflux temperature (85°C to 86°C) and was dehydrated by distilling off 66.5 g 1,2-dichloroethane. While maintaining at reflux, 30 g chlorosulfonic acid was added slowly over a period of about two hours. The rate of addition was regulated by the speed of evolution of the HCl. After all the chlorosulfonic acid was added, the charge was still maintained at reflux for an additional 15 minutes to remove traces of HCl. It was then cooled to 5°C and filtered. The filter cake was washed with 500 g cold 1,2-dichloroethane and dried. 98 g of product were obtained.
brand name
Sungard (Bayer).
Therapeutic Function
Sunscreen agent
General Description
Sulisobenzone is a broad spectrum organic UV filter in sunscreen formulations, known to absorb deleterious UV light.
Flammability and Explosibility
Non flammable
Contact allergens
BZP-4 is widely used in cosmetics, particularly shampoos and hair products. Cross-reactivity is rarely expected in patients photoallergic to ketoprofen.
Properties of 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
Melting point: | 170 °C |
Boiling point: | 0°C |
Density | 1.4574 (rough estimate) |
vapor pressure | 0Pa at 25℃ |
refractive index | 1.5300 (estimate) |
Flash point: | 0°C |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | -0.70±0.50(Predicted) |
form | neat |
form | Solid |
color | White to Off-White |
Water Solubility | 300.92g/L at 25℃ |
Merck | 14,8983 |
BRN | 2889165 |
CAS DataBase Reference | 4065-45-6(CAS DataBase Reference) |
EPA Substance Registry System | Sulisobenzone (4065-45-6) |
Safety information for 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. |
Computed Descriptors for 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
InChIKey | CXVGEDCSTKKODG-UHFFFAOYSA-N |
Abamectin manufacturer
Salicylates and Chemicals Pvt. Ltd.
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