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HomeProduct name list4-Chloroanisole

4-Chloroanisole

  • CAS NO.:623-12-1
  • Empirical Formula: C7H7ClO
  • Molecular Weight: 142.58
  • MDL number: MFCD00000616
  • EINECS: 210-772-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-21 22:41:43
4-Chloroanisole Structural

What is 4-Chloroanisole?

Chemical properties

colourless liquid

The Uses of 4-Chloroanisole

4-Chloroanisole was found to react with Cu (II)-smectite forming a blue clay-organic complex. 4-Chloroanisole was chosen as the main test substrate for the optimisation studies as it is electronically deactivated and thus resistant to oxidative addition and consequently very reluctant to enter a catalytic manifold.

Synthesis Reference(s)

Chemistry Letters, 16, p. 1901, 1987
The Journal of Organic Chemistry, 35, p. 528, 1970 DOI: 10.1021/jo00827a060

General Description

4-Chloroanisole is an electron-rich chloroarene. It undergoes Ullmann-type homocoupling catalyzed by in situ generated Pd colloids. Reaction of 4-chloroanisole with Cu(II)-smectite in n-hexane, carbon tetrachloride or dichloromethane has been studied. The nucleophilic photosubstitution reactions, photocyanation and photohydrolysis of 4-chloroanisole has been studied by time resolved spectroscopy.

Purification Methods

Wash the anisole with 10% (by volume) aqueous H2SO4 (three times), 10% aqueous KOH (three times), and then with water until neutral. Dry it (MgSO4), and fractionally distil it from CaH2 through a glass helices-packed column under reduced pressure. [Beilstein 16 IV 822.]

Properties of 4-Chloroanisole

Melting point: -18 °C (lit.)
Boiling point: 198-202 °C (lit.)
Density  1.164 g/mL at 25 °C (lit.)
vapor pressure  1.08hPa at 25℃
refractive index  n20/D 1.535(lit.)
Flash point: 173 °F
storage temp.  Sealed in dry,Room Temperature
form  Liquid
color  Clear colorless to yellow
Water Solubility  immiscible
BRN  1858901
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference 623-12-1(CAS DataBase Reference)
NIST Chemistry Reference Benzene, 1-chloro-4-methoxy-(623-12-1)
EPA Substance Registry System Benzene, 1-chloro-4-methoxy- (623-12-1)

Safety information for 4-Chloroanisole

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H227:Flammable liquids
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P403+P235:Store in a well-ventilated place. Keep cool.
P501:Dispose of contents/container to..…

Computed Descriptors for 4-Chloroanisole

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