4-Chloroanisole
- CAS NO.:623-12-1
- Empirical Formula: C7H7ClO
- Molecular Weight: 142.58
- MDL number: MFCD00000616
- EINECS: 210-772-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is 4-Chloroanisole?
Chemical properties
colourless liquid
The Uses of 4-Chloroanisole
4-Chloroanisole was found to react with Cu (II)-smectite forming a blue clay-organic complex. 4-Chloroanisole was chosen as the main test substrate for the optimisation studies as it is electronically deactivated and thus resistant to oxidative addition and consequently very reluctant to enter a catalytic manifold.
Synthesis Reference(s)
Chemistry Letters, 16, p. 1901, 1987
The Journal of Organic Chemistry, 35, p. 528, 1970 DOI: 10.1021/jo00827a060
General Description
4-Chloroanisole is an electron-rich chloroarene. It undergoes Ullmann-type homocoupling catalyzed by in situ generated Pd colloids. Reaction of 4-chloroanisole with Cu(II)-smectite in n-hexane, carbon tetrachloride or dichloromethane has been studied. The nucleophilic photosubstitution reactions, photocyanation and photohydrolysis of 4-chloroanisole has been studied by time resolved spectroscopy.
Purification Methods
Wash the anisole with 10% (by volume) aqueous H2SO4 (three times), 10% aqueous KOH (three times), and then with water until neutral. Dry it (MgSO4), and fractionally distil it from CaH2 through a glass helices-packed column under reduced pressure. [Beilstein 16 IV 822.]
Properties of 4-Chloroanisole
Melting point: | -18 °C (lit.) |
Boiling point: | 198-202 °C (lit.) |
Density | 1.164 g/mL at 25 °C (lit.) |
vapor pressure | 1.08hPa at 25℃ |
refractive index | n |
Flash point: | 173 °F |
storage temp. | Sealed in dry,Room Temperature |
form | Liquid |
color | Clear colorless to yellow |
Water Solubility | immiscible |
BRN | 1858901 |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 623-12-1(CAS DataBase Reference) |
NIST Chemistry Reference | Benzene, 1-chloro-4-methoxy-(623-12-1) |
EPA Substance Registry System | Benzene, 1-chloro-4-methoxy- (623-12-1) |
Safety information for 4-Chloroanisole
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H227:Flammable liquids |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for 4-Chloroanisole
Abamectin manufacturer
Syn Finechem Laboratories Pvt Ltd.
Super Hygienic Chemicals
BASR Fine Chemicals Pvt. Ltd.
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