4-Chloro-2-nitroaniline
Synonym(s):1-Amino-4-chloro-2-nitrobenzene
- CAS NO.:89-63-4
- Empirical Formula: C6H5ClN2O2
- Molecular Weight: 172.57
- MDL number: MFCD00007836
- EINECS: 201-925-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-10-21 09:22:16
What is 4-Chloro-2-nitroaniline ?
Chemical properties
bright orange powder
The Uses of 4-Chloro-2-nitroaniline
4-Chloro-2-nitroaniline is used almost exclusively as an intermediate in the synthesis of pigments. The greatest potential for human exposure to 4-chloro-2- nitroaniline is in production and use of pigments made from the compound.
The Uses of 4-Chloro-2-nitroaniline
A nitro-aromatic amine with mutagenicity and carcinogenicity
The Uses of 4-Chloro-2-nitroaniline
4-Chloro-2-nitroaniline is used as pharmaceutical intermediate.
Preparation
4-Chloro-2-nitrobenzenamine of chlorine.
Production Methods
1,4-Dichloro-2-nitrobenzene is aminated at 165 ℃ by using a process similar to that described for 2- nitroaniline.
General Description
Bright orange powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
4-Chloro-2-nitroaniline forms explosive products on reaction with nitric acid. Can react with oxidizing agents.
Hazard
Toxic by ingestion and inhalation.
Fire Hazard
4-Chloro-2-nitroaniline is probably combustible.
Purification Methods
Crystallise the aniline from hot H2O (m 115.8-116o), EtOH, EtOH/H2O or *C6H6, and dry it for 10hours at 60o in vacuo. It has m 115.5-116o after sublimation. [Beilstein 12 H 729, 12 I 355, 12 II 396, 12 III 1649, 12 IV 1669.]
Properties of 4-Chloro-2-nitroaniline
Melting point: | 117-119 °C(lit.) |
Boiling point: | 200°C (rough estimate) |
Density | 1.37 |
refractive index | 1.6460 (estimate) |
Flash point: | 191 °C |
storage temp. | room temp |
solubility | 0.5g/l (anhydrous substance) |
pka | pK1: 1.10(+1) (25°C) |
Colour Index | 37040 |
form | Crystalline Powder or Chunks |
color | Orange |
PH | 7 (0.5g/l, H2O, 20℃) |
Water Solubility | INSOLUBLE |
BRN | 512436 |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 89-63-4(CAS DataBase Reference) |
NIST Chemistry Reference | Aniline, 4-chloro-2-nitro-(89-63-4) |
EPA Substance Registry System | 4-Chloro-2-nitroaniline (89-63-4) |
Safety information for 4-Chloro-2-nitroaniline
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09 |
GHS Hazard Statements |
H373:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P262:Do not get in eyes, on skin, or on clothing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P314:Get medical advice/attention if you feel unwell. |
Computed Descriptors for 4-Chloro-2-nitroaniline
New Products
Tubulysin B (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin C (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride tetrahydro-4-methyl-2H-pyran 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 4-Methylenepiperidine HCl tert-Butyl (azetidin-3-yl)carbamate hydrochloride Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate (S)-3-Aminobutanenitrile hydrochloride 2-Amino-3-bromo-5-nitropyridine N-(2-methoxy-5-nitrophenyl)acetamide N-[2-(Acetylthio)-1-oxobutyl]glycine ethyl ester 5-Bromo-2-chloroisonicotinic acid methyl 2-bromobenzoate 4-chloro-2-hydroxy-5-nitropyridine 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrile (2S)-3-Methyl-2-(methylamino)-1-butanol (2R,3S)-2-Azido-3-methylpentanoic acid FUSIDIC ACID EP IMPURITY H / FUSIDIC ACID BP IMPURITY H / 11-KETO FUSIDIC ACID Sertraline EP Impurity C / Sertraline BP Impurity C / rac-cis-3-Dechloro Sertraline HCl Montelukast (3S)-Hydroxy BenzoateRelated products of tetrahydrofuran
You may like
-
4-Chloro-2-nitroaniline CAS 89-63-4View Details
89-63-4 -
p-Chloro-o-nitroaniline 98% CAS 89-63-4View Details
89-63-4 -
4-Chloro-2-nitroaniline CAS 89-63-4View Details
89-63-4 -
p-CHLORO-o-NITROANILINE For Synthesis CAS 89-63-4View Details
89-63-4 -
7664-41-7View Details
7664-41-7 -
Lithium Chloride (0.5 M in THF) 7447-41-8View Details
7447-41-8 -
7786-30-3 Magnesium Chloride (1.0 M in THF)View Details
7786-30-3 -
75-29-6 2-Chloropropane (25%M in THF)View Details
75-29-6