4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline

CAS NO.：694499-26-8
Empirical Formula: C13H18F3N3
Molecular Weight: 273.3
MDL number: MFCD09909924
SAFETY DATA SHEET (SDS)
Update Date: 2024-06-25 20:17:06

What is 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline?

The Uses of 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline

4-(6-Acryloyloxyhexyloxy)-benzoesure (4-cyanophenylester) can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and in the process of chemical and pharmaceutical synthesis.

Synthesis

Synthesis_694499-26-8
4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline Into a solution 4-methyl-1-(4-nitro-2-(trifluoromethyl)benzyl)piperazine (1.5 g, 5 mmol) in MeOH (250 mL) was added Raney Nickel (0.15 g, 10 wt %). The suspension was stirred under hydrogen atmosphere (50 psi) for 24 hrs and monitored by TLC. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure to yield the desired product (1.36 g, 100%). 1H NMR (300 MHz, CDCl3) |?: 7.43-7.46 (1H, d, J=9.0 Hz), 6.91 (1H, s), 6.77-6.80 (1H, d J=9.0 Hz), 3.77 (2H, s), 3.54 (2H, s), 2.53 (8H, brs), 2.34 (3H, s).

storage

Store long-term at 2-8°C.

Properties of 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline

Boiling point:	329.1±42.0 °C(Predicted)
Density	1.227
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	7.55±0.10(Predicted)
InChI	InChI=1S/C13H18F3N3/c1-18-4-6-19(7-5-18)9-10-2-3-11(17)8-12(10)13(14,15)16/h2-3,8H,4-7,9,17H2,1H3

Safety information for 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection.