3,5-Dichlorophenol

CAS NO.：591-35-5
Empirical Formula: C6H4Cl2O
Molecular Weight: 163
MDL number: MFCD00002259
EINECS: 209-714-9
SAFETY DATA SHEET (SDS)
Update Date: 2023-10-08 15:17:26

What is 3,5-Dichlorophenol?

Chemical properties

yellow to light brown crystals, crystalline powder

The Uses of 3,5-Dichlorophenol

3,5-Dichlorophenol is used as pharmaceutical intermediate.

Definition

ChEBI: 3,5-dichlorophenol is a dichlorophenol in which the two chloro substituents are located at positions 3 and 5.

What are the applications of Application

3,5-Dichlorophenol is a metabolite of the pesticides polychlorinated phenols and benzene hexachloride. found in chlorinated waste water; Used as a research chemical.

Preparation

Catalytic hydrodechlorination of polychlorophenols in organic or aqueous media with a palladium catalyst was used to obtain 3-chlorophenol and 3,5-dichlorophenol.

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 4565, 1984 DOI: 10.1016/S0040-4039(01)81494-5

General Description

Prisms (from petroleum ether) or pink crystals.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

3,5-Dichlorophenol is incompatible with acid chlorides, acid anhydrides and oxidizing agents.

Fire Hazard

Flash point data for 3,5-Dichlorophenol are not available. 3,5-Dichlorophenol is probably combustible.

Purification Methods

Crystallise 3,5-dichlorophenol from pet ether/*benzene mixture and/or distil it. [Beilstein 6 IV 957.]

Properties of 3,5-Dichlorophenol

Melting point:	65-68 °C (lit.)
Boiling point:	233 °C (lit.)
Density	1.3446 (rough estimate)
refractive index	1.4430 (estimate)
Flash point:	233°C
storage temp.	room temp
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
pka	pKa 8.48(H2O t=25 I=0.025) (Uncertain)
form	Crystals, Crystalline Powder or Crystalline Mass
color	Yellow to light brown
Water Solubility	Slightly soluble in water. Very soluble in ethanol, ethyl ether and petroleum ether.
BRN	1906458
CAS DataBase Reference	591-35-5(CAS DataBase Reference)
NIST Chemistry Reference	Phenol, 3,5-dichloro-(591-35-5)
EPA Substance Registry System	3,5-Dichlorophenol (591-35-5)

Safety information for 3,5-Dichlorophenol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H311:Acute toxicity,dermal H314:Skin corrosion/irritation H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.