3,3,5-Trimethylcyclohexanol

Synonym(s):3,3,5-Trimethylcyclohexanol;Homomenthol, Dihydroisophorol

CAS NO.：116-02-9
Empirical Formula: C9H18O
Molecular Weight: 142.24
MDL number: MFCD00019378
EINECS: 204-122-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-06-27 11:49:20

What is 3,3,5-Trimethylcyclohexanol?

Chemical properties

WHITE CRYSTALLINE MASS. Soluble in most organic solvents, hydrocarbons, oils; insoluble in water. Combustible.

Chemical properties

3,3,5-Trimethyl cyclohexanol has a menthol-like camphorous odor.

Occurrence

Has apparently not been reported to occur in nature.

The Uses of 3,3,5-Trimethylcyclohexanol

Menthol and camphor substitute, antifoaming agent, hydraulic fluids and textile soaps, odor masking, esterification agent, pharmaceuticals,wax additive, printing inks.

Definition

ChEBI: A secondary alcohol that is cyclohexanol substituted by two methyl groups at the 3-position and one methyl group at the 5-position. It exhibits inhibitory activity against HMG-CoA reductase ( EC 1.1.1.34/EC 1.1.1.88).

Preparation

By complete hydrogenation of isophorone (Arctander, 1969).

Synthesis Reference(s)

Tetrahedron, 37, p. 1171, 1981 DOI: 10.1016/S0040-4020(01)92046-0

Hazard

Toxic by inhalation, strong irritant.

Synthesis

Trimethyl cyclohexanol is synthesized by complete hydrogenation of isoPhorone. Dehydration of the title material with Zinc chloride yields alpha-Cyclogeraniolene.

Properties of 3,3,5-Trimethylcyclohexanol

Melting point:	30-32 °C
Boiling point:	193-196 °C
Density	0.86
vapor pressure	1 hPa (50 °C)
refractive index	1.4559 (estimate)
FEMA	3962 \| 3,5,5-TRIMETHYLCYCLOHEXANOL
Flash point:	81 °C
storage temp.	Store below +30°C.
form	powder to lump to clear liquid
pka	15.35±0.60(Predicted)
color	A translucent, colourless, fused mass or crystals with a powerful menthol-like odour
PH	7 (1.8g/l, H2O, 20°C)
Odor	at 100.00 %. mint cool mentholic musty spicy
explosive limit	1.5%(V)
Water Solubility	1.8 g/L (20 ºC)
JECFA Number	1099
CAS DataBase Reference	116-02-9(CAS DataBase Reference)
NIST Chemistry Reference	Cyclohexanol, 3,3,5-trimethyl-(116-02-9)
EPA Substance Registry System	Cyclohexanol, 3,3,5-trimethyl- (116-02-9)

Safety information for 3,3,5-Trimethylcyclohexanol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention.