1-Ethynyl-1-cyclohexanol
Synonym(s):1-Ethynylcyclohexanol
- CAS NO.：78-27-3
- Empirical Formula: C8H12O
- Molecular Weight: 124.18
- MDL number: MFCD00003858
- EINECS: 201-100-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is 1-Ethynyl-1-cyclohexanol?
Chemical properties
Colorless liquid
The Uses of 1-Ethynyl-1-cyclohexanol
1-Ethynyl-1-cyclohexanol (ECHO) can undergo acetylation in the presence of a catalytic amount of ruthenium chloride at room temperature. It can be used to synthesize novel organotellurium(IV) compounds with potent inhibitory activity towards Cathepsin B. The polymerization of ECHO by transition metal catalysts leads to the formation of poly(ECHO). It can also react with transition metal hydride complexes to form vinyl derivatives by inserting into the M-H bonds.
The Uses of 1-Ethynyl-1-cyclohexanol
Stabilization of chlorinated organic compounds, intermediate, corrosion inhibitor for mineral acids, medicine (sedative).
Synthesis Reference(s)
Organic Syntheses, Coll. Vol. 3, p. 416, 1955
Synthetic Communications, 18, p. 131, 1988 DOI: 10.1080/00397918808077336
Flammability and Explosibility
Non flammable
Properties of 1-Ethynyl-1-cyclohexanol
| Melting point: | 30-33 °C(lit.) |
| Boiling point: | 180 °C(lit.) |
| Density | 0.967 g/mL at 25 °C(lit.) |
| vapor pressure | <1 mm Hg ( 20 °C) |
| refractive index | 1.481-1.484 |
| Flash point: | 163 °F |
| storage temp. | Store below +30°C. |
| solubility | 10 g/L (20°C) |
| form | Liquid After Melting |
| pka | 13.34±0.20(Predicted) |
| color | Clear colorless to light yellow |
| PH | 7 (1g/l, H2O, 20℃) |
| explosive limit | 1.3-8.7%(V) |
| Water Solubility | 10 g/L (20 ºC) |
| BRN | 471404 |
| CAS DataBase Reference | 78-27-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Cyclohexanol, 1-ethynyl-(78-27-3) |
| EPA Substance Registry System | Cyclohexanol, 1-ethynyl- (78-27-3) |
Safety information for 1-Ethynyl-1-cyclohexanol
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H311:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-Ethynyl-1-cyclohexanol
| InChIKey | QYLFHLNFIHBCPR-UHFFFAOYSA-N |
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