3,3',5-TRIIODOTHYROACETIC ACID
Synonym(s):4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenylacetic acid
- CAS NO.:51-24-1
- Empirical Formula: C14H9I3O4
- Molecular Weight: 621.93
- MDL number: MFCD00055931
- EINECS: 200-086-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-14 14:09:35
What is 3,3',5-TRIIODOTHYROACETIC ACID?
Chemical properties
White to Off-White Solid
Originator
Triacana,Ana,Italy,1972
The Uses of 3,3',5-TRIIODOTHYROACETIC ACID
Thyroid hormone analogue
The Uses of 3,3',5-TRIIODOTHYROACETIC ACID
thyroid agent
The Uses of 3,3',5-TRIIODOTHYROACETIC ACID
3,3'',5-Triiodo Thyroacetic Acid (T3-Acetic Acid (USP)) is a thyroid hormone analogue. A potent Thyroxine impurity. Levothyroxine EP Impurity C.
Manufacturing Process
Preparation of 3:5-diiodo-4-(4'-hydroxyphenoxy)phenylacetic acid (diacid): A
solution of ethyl 3:5-diiodo-4-(4'-methoxyphenoxy)phenyl acetate (9.5 g) in
acetic acid (60 ml) was heated under reflux with hydroiodic acid (SG 1.7, 50
ml) and red phosphorus (0.5 g) for 1 hour. The hot solution was filtered and
the filtrate concentrated at 50°C and 15 mm of mercury to above 20 ml. The
residue was treated with water (70 ml) containing a little sodium thiosulfate
to decolorize the product. The solid was collected by filtration and purified by
the method of Harington and Pitt-Rivers [Biochem. J. (1952), Vol. 50, page
438]. Yield 8.36 g (95%). After crystallization from 70% (v/v) acetic acid it
melted at 219°C.
A solution of 438 mg of diac in methanol (20 ml) and ammonia solution (SG
0.88; 20 ml) was iodinated at 0°C with 1.8 ml 1 N iodine solution. The
product was isolated in almost theoretical yield in a manner similar to that
described for tetrac. After crystallization from 50% (v/v) methanol, triac was
obtained as colorless needles which melted over the range 65°C to 90°C
according to the rate of heating. The molten form resolidified at about 110°C
and finally melted at 180°C to 181°C without decomposition. The compound,
dried at 25°C/3 mm over silica gel, contains methanol of crystallization.
Therapeutic Function
Thyroid hormone
Properties of 3,3',5-TRIIODOTHYROACETIC ACID
Melting point: | 65°; mp 180-183° |
Boiling point: | 531.6±50.0 °C(Predicted) |
Density | 2.466±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated) |
form | Solid |
pka | 4.02±0.10(Predicted) |
color | White to Pale Beige |
Safety information for 3,3',5-TRIIODOTHYROACETIC ACID
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for 3,3',5-TRIIODOTHYROACETIC ACID
Abamectin manufacturer
Orgamine Chemicals(I) Pvt Ltd
Allmpus Laboratories Pvt Ltd
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