3,5-Diiodo-L-thyronine
Synonym(s):3,5-Diiodo-4-(4-hydroxyphenoxy)-L -phenylalanine;3,5-T2;O-(4-Hydroxyphenyl)-3,5-diiodo-L -tyrosine
- CAS NO.：1041-01-6
- Empirical Formula: C15H13I2NO4
- Molecular Weight: 525.08
- MDL number: MFCD00064987
- EINECS: 213-867-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is 3,5-Diiodo-L-thyronine?
Chemical properties
[α] 25 D +25.2° [5 % solution in 1 M HCl:95 % ethanol (1:2)], off-White Solid.
The Uses of 3,5-Diiodo-L-thyronine
3,5-Diiodo-L-thyronine is an iodinated thyronine hormone that regulates gene activity affecting processes such as homeostasis, lipid metabolism and insulin resistance.
The Uses of 3,5-Diiodo-L-thyronine
Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism.
Definition
ChEBI: (2S)-2-amino-3-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]propanoic acid is a phenylalanine derivative.
What are the applications of Application
3,5-Diiodo-L-thyronine is an iodinated thyronine hormone that regulates activity
Flammability and Explosibility
Not classified
Pharmacology
3,5-Diiodo-L-thyronine is a thyroid hormone with a l-thyroxine-like activity.
Purification Methods
Recrystallise it from EtOH. [Chambers et al. J Chem Soc 3424 1949, Beilstein 14 II 226, 14 III 1565, 14 IV 2372.]
Properties of 3,5-Diiodo-L-thyronine
| Melting point: | 255-260 °C (dec.) |
| Boiling point: | 559.4±50.0 °C(Predicted) |
| Density | 2.095±0.06 g/cm3(Predicted) |
| vapor pressure | 0.011Pa at 45℃ |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | Acidic Alcohol (Slightly), Aqueous Base (Slightly) |
| form | Solid |
| pka | 2.15±0.30(Predicted) |
| color | White to Light Brown |
| Water Solubility | 20.147mg/L at 20℃ |
| BRN | 2707891 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 1041-01-6(CAS DataBase Reference) |
Safety information for 3,5-Diiodo-L-thyronine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3,5-Diiodo-L-thyronine
| InChIKey | ZHSOTLOTTDYIIK-ZDUSSCGKSA-N |
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