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HomeProduct name list3-Methylpiperidine

3-Methylpiperidine

Synonym(s):β-Pipecoline;3-Pipecoline

  • CAS NO.:626-56-2
  • Empirical Formula: C6H13N
  • Molecular Weight: 99.17
  • MDL number: MFCD00005994
  • EINECS: 210-953-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
3-Methylpiperidine Structural

What is 3-Methylpiperidine?

Chemical properties

clear colorless to yellow liquid

The Uses of 3-Methylpiperidine

3-Methylpiperidine, is used as a reactant for synthesis of Phenylpropenamide derivatives for anti-hepatitis B virus activity, CB2 receptor agonists for treatment of chronic pain, aurora kinase inhibitors, spiroimidazolidinone NPC1L1 inhibitors, 1,3,5-Oxadiazinones, selective serotonin 5-HT6 receptor antagonists. It is also used as a pharmaceutical intermediate and as a intermediate in organic synthesis.

General Description

A colorless liquid with a characteristic odor. Less dense than water. Flash point less than 141°F. Contact may cause severe irritation to skin, eyes, and mucous membranes. Toxic by ingestion, inhalation and skin absorption.

Air & Water Reactions

Highly flammable. Water soluble.

Reactivity Profile

3-METHYLPIPERIDINE neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Generates flammable gaseous hydrogen in combination with strong reducing agents, such as hydrides.

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Purification Methods

Purify it via the hydrochloride (m 172o). The hydrobromide has m 162-163o(from iso-PrOH). [Chapman et al. J Chem Soc 1925 1959, Beilstein 20 III/IV 1499, 20/4 V 100.]

Properties of 3-Methylpiperidine

Melting point: -24 °C
Boiling point: 125-126 °C/763 mmHg (lit.)
Density  0.845 g/mL at 25 °C (lit.)
refractive index  n20/D 1.447(lit.)
Flash point: 63 °F
storage temp.  Flammables area
form  clear liquid
pka pK1:11.07(+1) (25°C)
color  Colorless to Light yellow to Light orange
Water Solubility  miscible
BRN  79807
CAS DataBase Reference 626-56-2(CAS DataBase Reference)
NIST Chemistry Reference Piperidine, 3-methyl-(626-56-2)
EPA Substance Registry System Piperidine, 3-methyl- (626-56-2)

Safety information for 3-Methylpiperidine

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H225:Flammable liquids
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 3-Methylpiperidine

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