3-Hydroxypicolinic acid
Synonym(s):3-HPA;3-Hydroxypicolinic acid;3-Hydroxypyridine-2-carboxylic acid
- CAS NO.：874-24-8
- Empirical Formula: C6H5NO3
- Molecular Weight: 139.11
- MDL number: MFCD00006294
- EINECS: 212-859-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:11
What is 3-Hydroxypicolinic acid?
Chemical properties
Light yellow Needles
The Uses of 3-Hydroxypicolinic acid
3-Hydroxypicolinic acid (3-HPA) is a matrix material used in matrix-assisted laser desorption/ionization (MALDI) based mass spectroscopy (MS) for the analysis of large biomolecules and quantification of oligonucleotides.
Definition
ChEBI: A monohydroxypyridine that is picolinic acid in which the hydrogen at position 3 is replaced by a hydroxy group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of oligonucleotides.
Properties of 3-Hydroxypicolinic acid
| Melting point: | 213-218 °C (lit.) |
| Boiling point: | 255.04°C (rough estimate) |
| Density | 1.4429 (rough estimate) |
| refractive index | 1.5423 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Acetonitrile (Slightly), DMSO (Slightly) |
| form | Fine Powder |
| pka | 1.14±0.50(Predicted) |
| color | White to almost white |
| Water Solubility | Soluble in water (0.25g in 10ml). |
| BRN | 118954 |
| CAS DataBase Reference | 874-24-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-Hydroxypicolinic acid(874-24-8) |
Safety information for 3-Hydroxypicolinic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-Hydroxypicolinic acid
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