3-Hydroxypyridine
Synonym(s):3-Pyridinol;3-Pyridone
- CAS NO.:109-00-2
- Empirical Formula: C5H5NO
- Molecular Weight: 95.1
- MDL number: MFCD00006378
- EINECS: 203-637-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is 3-Hydroxypyridine?
Chemical properties
white to light yellow crystal. Soluble in alcohol and water, slightly soluble in ether and benzene. It becomes a red solution when it encounters ferric chloride, and it is easy to decompose in the air.
The Uses of 3-Hydroxypyridine
3-Hydroxypyridine (cas# 109-00-2) is a compound useful in organic synthesis.
Definition
ChEBI: 3-Hydroxypyridine is a monohydroxypyridine that is pyridine in which the hydrogen at position 3 has been replaced by a hydroxy group. It has been detected as a thermal degradation product from the smoke of the burning leaves of Salvia divinorum, a Mexican psychoactive plant.
Preparation
3-hydroxypyridine was prepared by reacting furfurylamine with H2O2 in the presence of HCl, followed by hydrolysis. The optimal conditions were found as fellows: molar ratio of furfurylamine: HCl : H2O2 = 1 : 5 : 1.1, and H2O2 added dropwisely at 0-5 °C, and then refluxed at 100-105 °C for 0.5 h.
brand name
Ventavis (Schering).
Purification Methods
Crystallise 3-hydroxypyridine from *C6H6, water or EtOH. [Beilstein 21 III/IV 402, 21/2 V 68.]
Properties of 3-Hydroxypyridine
Melting point: | 125-128 °C (lit.) |
Boiling point: | 280-281 °C(lit.) |
Density | 1.1418 (rough estimate) |
refractive index | 1.5939 (estimate) |
Flash point: | 173°C |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | 33g/l |
form | Crystalline Powder |
pka | 4.79, 8.75(at 20℃) |
color | Beige to brown |
PH | 6.0-6.5 (33g/l, H2O, 20℃) |
Water Solubility | 32.26g/L(20 ºC) |
BRN | 105699 |
CAS DataBase Reference | 109-00-2(CAS DataBase Reference) |
NIST Chemistry Reference | 3-Pyridinol(109-00-2) |
EPA Substance Registry System | 3-Pyridinol (109-00-2) |
Safety information for 3-Hydroxypyridine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-Hydroxypyridine
Abamectin manufacturer
ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED
Sintilla Medcoms Pvt Ltd
Rivashaa Agrotech Biopharma Pvt. Ltd.
Madin Life Sciences Pvt Ltd
Galaxy Laboratories Private Limited
ARRAKIS INDUSTRIES LLP
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