3-Hydroxy-1-methylpiperidine

Synonym(s):1-Methyl-3-piperidinol;3-Hydroxy-1-methylpiperidine

CAS NO.：3554-74-3
Empirical Formula: C6H13NO
Molecular Weight: 115.17
MDL number: MFCD00006495
EINECS: 222-609-2
SAFETY DATA SHEET (SDS)
Update Date: 2025-10-23 17:25:30

What is 3-Hydroxy-1-methylpiperidine?

The Uses of 3-Hydroxy-1-methylpiperidine

Reactant for:• ;Optimization of Novobiocin scaffold to produce antitumor agents1• ;Formation of carbamates and N-alkylimidazoles2Reactant for synthesis of:• ;Pyridine derivatives as CDK5 inhibitors3• ;Phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors4• ;Amino phosphite ligands5• ;Mexiletine enantiomers by nucleophilic aromatic substitution6

The Uses of 3-Hydroxy-1-methylpiperidine

Reactant for Optimization of Novobiocin scaffold to produce antitumor agents, Formation of carbamates and N-alkylimidazoles. Reactant for synthesis of Pyridine derivatives as CDK5 inhibitors Phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors, Amino phosphite ligands, Mexiletine enantiomers by nucleophilic aromatic substitution.

The Uses of 3-Hydroxy-1-methylpiperidine

Reactant for:

Optimization of Novobiocin scaffold to produce antitumor agents
Formation of carbamates and N-alkylimidazoles

Reactant for synthesis of:

Pyridine derivatives as CDK5 inhibitors
Phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors
Amino phosphite ligands
Mexiletine enantiomers by nucleophilic aromatic substitution

Properties of 3-Hydroxy-1-methylpiperidine

Boiling point:	76-78 °C11 mm Hg(lit.)
Density	0.999 g/mL at 25 °C(lit.)
refractive index	n20/D 1.475
Flash point:	158 °F
pka	14.95±0.20(Predicted)
color	Clear, orange
Water Solubility	Fully misicible in water.
BRN	103017
CAS DataBase Reference	3554-74-3(CAS DataBase Reference)
NIST Chemistry Reference	3-Piperidinol, 1-methyl-(3554-74-3)
EPA Substance Registry System	3-Piperidinol, 1-methyl- (3554-74-3)

Safety information for 3-Hydroxy-1-methylpiperidine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.