3-(2-Chlorophenyl)-5-methylisoxazole-4-carbonyl chloride
- CAS NO.:25629-50-9
- Empirical Formula: C11H7Cl2NO2
- Molecular Weight: 256.08
- MDL number: MFCD00020811
- EINECS: 247-137-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-30 16:49:16
What is 3-(2-Chlorophenyl)-5-methylisoxazole-4-carbonyl chloride?
Chemical properties
3-(2-Chlorophenyl)-5-methylisoxazole-4-carbonyl chloride is Cream solid
The Uses of 3-(2-Chlorophenyl)-5-methylisoxazole-4-carbonyl chloride
3-(2-Chlorophenyl)-5-methylisoxazole-4-carbonyl chloride is used for preparing isoxazolyl penicillin derivatives.
Flammability and Explosibility
Not classified
Synthesis
To the solution was dropwise added under cooling at -12° to -14°C a solution of 3-(2-chlorophenyl)-5-methylisoxazol-4-carbonyl chloride, which was prepared from 3-(2-chlorophenyl)-5-methylisoxazol-4-carboxylic acid (1.78 g.) and thionyl chloride (10 ml.), in methylene chloride and then stirred for 5 hours. After the reaction, to the solution was added ice-water, and the resulant mixture was washed with water, dilute phosphoric acid, an aqueous solution of sodium bicarbonate and water in turn, and dried over magnesium sulfate.
Properties of 3-(2-Chlorophenyl)-5-methylisoxazole-4-carbonyl chloride
Melting point: | 41-42°C |
Boiling point: | 381.7±42.0 °C(Predicted) |
Density | 1.381±0.06 g/cm3(Predicted) |
vapor pressure | 0.001Pa at 25℃ |
pka | -5.80±0.50(Predicted) |
color | White to off-white |
Water Solubility | 128.2mg/L at 25℃ |
Sensitive | Moisture Sensitive |
BRN | 791931 |
CAS DataBase Reference | 25629-50-9(CAS DataBase Reference) |
EPA Substance Registry System | 4-Isoxazolecarbonyl chloride, 3-(2-chlorophenyl)-5-methyl- (25629-50-9) |
Safety information for 3-(2-Chlorophenyl)-5-methylisoxazole-4-carbonyl chloride
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 3-(2-Chlorophenyl)-5-methylisoxazole-4-carbonyl chloride
Abamectin manufacturer
Arch Pharmalabs Ltd
Medec Dragon Private Limited
Penam Laboratories Ltd
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