(2S)-Bornane-10,2-sultam

Synonym(s):(+)-10,2-Camphorsultam;(+)-exo-10,2-Bornanesultam;(1R,5S)-10,10-Dimethyl-3-thia-4-azatricyclo[5.2.1.0^1,5]decane 3,3-dioxide;L-2,10-Camphorsultam

CAS NO.：108448-77-7
Empirical Formula: C10H17NO2S
Molecular Weight: 215.31
MDL number: MFCD00151762
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-29 11:48:24

What is (2S)-Bornane-10,2-sultam?

Chemical properties

white to light yellow crystal powde

The Uses of (2S)-Bornane-10,2-sultam

(1R)-(+)-2,10-Camphorsultam has been used as a reactant in the synthesis of pyrrolidine acid analogs as potent dual PPARα/γ agonists.

Purification Methods

The (-)-enantiomer is recrystallised from 95% EtOH and dried in a vacuum desiccator. It dissolves in dilute aqueous NaOH and can be precipitated without hydrolysis by acidifying. It forms the N-Na salt in EtOH (by addition of Na to the EtOH solution), and the salt can be methylated with MeI to give the (-)-N-Me lactam with m 80o after recrystallisation from hot H2O and has []D -59.6o (c 5, CHCl3) [Shriner et al. J Am Chem Soc 60 2794 1938]. [Oppolzer et al. Helv Chim Acta 69 1142 1986, Weismiller et al. Org Synth 69 154 1955, Beilstein 27 III/IV 1007.]

Properties of (2S)-Bornane-10,2-sultam

Melting point:	185-187 °C(lit.)
Boiling point:	324.8±25.0 °C(Predicted)
alpha	33 º (c=4.9, CHCl3)
Density	1.1469 (rough estimate)
refractive index	31 ° (C=1, CHCl3)
storage temp.	Sealed in dry,Room Temperature
solubility	almost transparency in Chloroform
form	powder to crystal
pka	11.05±0.40(Predicted)
color	White to Almost white
optical activity	[α]20/D +32°, c = 5 in chloroform
BRN	4675755
CAS DataBase Reference	108448-77-7(CAS DataBase Reference)

Safety information for (2S)-Bornane-10,2-sultam

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.