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HomeProduct name list2,3-O-Isopropylidene-D-ribonic gamma-lactone

2,3-O-Isopropylidene-D-ribonic gamma-lactone

Synonym(s):2,3-O-Isopropylidene-D-ribono-1,4-lactone

2,3-O-Isopropylidene-D-ribonic gamma-lactone Structural

What is 2,3-O-Isopropylidene-D-ribonic gamma-lactone?

Description

2,3-Isopropylidene-D-ribonolactone is a building block. It has been used in the stereocontrolled synthesis of the carbohydrates 6-epi-trehazolin and 6-epi-trehalamine.

Chemical properties

White Crystalline Solid

The Uses of 2,3-O-Isopropylidene-D-ribonic gamma-lactone

2,3-O-Isopropylidene-D-ribonic acid-1,4-lactone is used for the synthesis of C-nucleosides, prostanoids and GABA analogs via homochiral 2-piperidones. It is the starting material for the preparation of biochemical compounds including C-nucleosides, such as neplanocin A, and GABA analogs, via homochiral 2-piperidones.

Properties of 2,3-O-Isopropylidene-D-ribonic gamma-lactone

Melting point: 135-139 °C
Boiling point: 243.17°C (rough estimate)
alpha  -68.5 º (c=2, Pyridine)
Density  1.2069 (rough estimate)
refractive index  1.4348 (estimate)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  Soluble in methanol at 50mg/ml, acetone, dichloromethane, ethyl Acetate.
form  Powder
pka 13.68±0.10(Predicted)
color  White to Off-white
optical activity [α]20/D 69°, c = 2 in pyridine
Water Solubility  soluble
BRN  10090
CAS DataBase Reference 30725-00-9(CAS DataBase Reference)

Safety information for 2,3-O-Isopropylidene-D-ribonic gamma-lactone

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2,3-O-Isopropylidene-D-ribonic gamma-lactone

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