3-Methyl-2-butanone

Description

MIPK is a colorless liquid with an acetonelike odor. Molecular weight = 86.15; Specific gravity(H2O:1) 5 0.81; Boiling point = 93℃. Freezingpoint 5 2 92℃; Vapor pressure 5 42 mmHg at 20℃; Flashpoint 5 6℃; Autoignition temperature 5 475℃. Explosivelimits: LEL 5 1.2%; UEL 5 8%. Hazard Identification(based on NFPA-704 M Rating System): Health 1,Flammability 4, Reactivity 0. Slightly soluble in water;solubility 5 0.5% at 20℃.

Chemical properties

CLEAR COLOURLESS LIQUID

Chemical properties

MIPK is a colorless liquid with an acetonelike odor. 3-Methyl-2-butanone is a colorless liquid with a characteristic ketone odor.3-Methyl-2-butanone undergoes condensation reactions preferentially at the methyl group. The tertiary carbon atom is easily oxidized and the resulting hydroperoxide (mp 26 – 27℃) can be produced by base-catalyzed air oxidation.

The Uses of 3-Methyl-2-butanone

3-Methyl-2-butanone is used for synthesis of heterocyclic compounds and important intermediate of medicine. It is used as an industrial solvent.

The Uses of 3-Methyl-2-butanone

Solvent for nitrocellulose lacquers. 3-Methyl-2-butanone is employed predominantly as an intermediate for the production of pharmaceuticals, herbicides, and dye precursors. It is also used in the synthesis of rubber auxiliaries and for the selective extraction of rare earth elements.

The Uses of 3-Methyl-2-butanone

Methyl isopropyl ketone (MIPK) is used asa solvent for lacquers.

Definition

ChEBI: 3-Methylbutan-2-one is a ketone.

Preparation

3-Methyl-2-butanone is produced by oxidation of Methyl-iso-propylcarbinol (2-Methyl-3-butanol).

General Description

A colorless liquid with a pleasant odor. Flash point below 70°F. Less dense than water. May be toxic by inhalation and skin absorption. Used as a solvent.

Air & Water Reactions

Highly flammable. Soluble in water.

Reactivity Profile

Ketones, such as 3-Methyl-2-butanone, are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Hazard

Toxic material. Embryo/fetal damage andneonatal toxicity.

Health Hazard

Irritating to the eyes, nose, throat, upper respiratory tract, and skin.

Health Hazard

The acute toxic effects from exposure to thevapors of MIPK are narcosis and irritationof the eyes, skin, and respiratory passages.In rabbits the irritation effect of 100 mg fora 24-hour exposure was mild in the eyes,while 500 mg was moderate on the skin. Thetoxicity data on this compound are too scant.In general, its toxicity is low and narcosissymptoms in humans may be felt only at veryhigh concentrations. In guinea pigs exposureto 5000 ppm caused coma.

Fire Hazard

Special Hazards of Combustion Products: Acrid smoke and fumes

Flammability and Explosibility

Highly flammable

Safety Profile

Poison by ingestion. Mildly toxic by inhalation and skin contact. Mutation data reported. A skin and eye irritant. Flammable when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes.

Potential Exposure

This ketone is used as a solvent for nitrocellulose lacquers.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.

storage

Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with this chemical you should be trainedon its proper handling and storage. Before entering confinedspace where this chemical may be present, check to makesure that an explosive concentration does not exist. Store intightly closed containers in a cool, well-ventilated areaaway from aldehydes. Sources of ignition, such as smokingand open flames, are prohibited where methyl isopropylketone is used, handled, or stored in a manner that couldcreate a potential fire or explosion hazard. Use only nonsparking tools and equipment, especially when opening andclosing containers of methyl isopropyl ketone. Wherevermethyl isopropyl ketone is used, handled, manufactured, orstored, use explosion-proof electrical equipment andfittings.

Shipping

UN23973-Methylbutan-2-one, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

Reflux the ketone with a little KMnO4. Fractionate it through a spinning-band column, dry with CaSO4 and distil it. [Beilstein 1 IV 3287.]

Incompatibilities

Vapors may form explosive mixture with air. Ketones are incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrated amines, azo, diazo, azido compounds, carbamates, organic cyanates

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.